Publications by authors named "Anabel Lin"
Extracellular vesicles (EVs) are membrane-bound particles secreted by cells with emerging roles in intercellular communication during tissue homeostasis and disease. Although EVs are abundant in respiratory biofluids, their cellular sources, critical cargos, and functions in the airway remain poorly understood. To determine how EV populations are changed in respiratory fluids during a chronic tissue inflammatory response, nasal EVs were assayed in 23 control participants and 22 participants with Aspirin-Exacerbated Respiratory Disease (AERD).
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- Platelets play a significant role in allergic asthma and aspirin-exacerbated respiratory disease (AERD) by being activated and influencing inflammatory responses.
- The study found that the GLP-1 receptor (GLP-1R) agonist liraglutide reduced platelet activation and airway resistance in a mouse model of AERD, indicating its potential therapeutic benefits.
- Liraglutide showed promise in inhibiting platelet activation in both mice and human patients with AERD, suggesting that targeting the GLP-1R could be a new strategy for managing asthma-related inflammation.