Publications by authors named "Anaam Hanut"
Article Synopsis
- This study focused on identifying genetic factors contributing to end-stage kidney disease (ESKD) in a minority group (Druze) in Israel, where existing data on genetic causes of chronic kidney disease are limited, particularly for minority populations.
- Researchers conducted whole-exome sequencing on 94 Druze patients undergoing dialysis, discovering genetic etiologies in about 18% of participants, including a novel WDR19 variant and other known genes associated with kidney disease.
- The findings highlight the importance of genetic testing in minority groups with high rates of chronic kidney disease, suggesting that certain genetic markers may go undiagnosed without comprehensive analysis, given that clinical diagnoses often did not match the final genetic results.
Diabetes mellitus (DM) is the leading cause of end stage renal disease; 40% of the patients worldwide will require replacement therapy after 20 years of DM. Early-stage diabetic nephropathy is characterized by hyper filtration with micro-and macro albuminuria. Later on end-stage renal disease (ESRD) can appear; 40% of diabetic patients develop micro-and macrovascular complications, with increased risk among patients with genetic predisposition, such as Haptoglobin 2-2 phenotype.
View Article and Find Full Text PDFArticle Synopsis
- Diabetic nephropathy (DN) is a major complication of diabetes, leading to end-stage renal disease, and is linked to low vitamin D levels due to decreased synthesis and receptor activity.
- In a study with diabetic mice, treatment with paricalcitol, an active vitamin D analog, showed potential benefits by restoring key protein levels and reducing kidney damage.
- Findings suggest that activating the vitamin D receptor with paricalcitol could help mitigate renal injury in diabetes by regulating important proteins involved in kidney function.