Publications by authors named "Ana-Teresa Mendoza"
Article Synopsis
- The peptide antibiotic teixobactin has a unique stereochemical pattern that is crucial for its strong antibiotic properties due to its special β-sheetlike structure.
- The study aimed to replace certain d-amino acids in teixobactin's structure with l-amino acids while keeping its amphiphilic nature.
- Results showed that changing specific residues to l-amino acids maintained antibiotic activity, but altering the stereochemistry at the N-terminal led to a decrease in effectiveness.
J Org Chem
September 2024
Article Synopsis
- The lab successfully synthesized the peptide antibiotic clovibactin on a larger scale, allowing for better study of its amino acid components.
- Key amino acids (Phe, d-Leu, Ser, Leu) were found to be crucial for the antibiotic's effectiveness, while modifications to the d-Hyn residue showed they could be adjusted with slight activity loss.
- Structural analysis through X-ray crystallography indicated that the macrolactone ring of clovibactin is vital for its antibiotic function, adopting a shape that can bind anions.
