Publications by authors named "Ana-Marija Stanic"
ACS Synth Biol
December 2024
Article Synopsis
- In vitro reconstructed minimal respiratory chains are used to study how enzyme components interact within their environment, particularly focusing on the coreconstitution of cytochrome oxidase and ATP synthase in liposomes.
- The study explores using natural long-chain ubiquinone and various electron donors like succinate or NADH, while revealing that negatively charged lipids are necessary for effective enzyme activity but also reduce ATP synthesis rates.
- To optimize enzyme orientation and ATP production, researchers utilize ionizable lipids that can switch charges based on pH, successfully enhancing ATP synthesis rates by aligning cytochrome oxidase for better function with NDH-2.
