Publications by authors named "Ana-Maria Merloiu"
Article Synopsis
- Recent studies indicate that disruptions in circadian rhythms are linked to arterial changes and increased vascular stiffness, affecting the body's endothelial responses and signaling.
- Reactive oxygen species, particularly from Nox4, have been identified as significant players in these vascular issues, with previous findings showing that circadian dysfunction leads to increased superoxide production.
- In this study, it was revealed that a dysfunctional circadian system (specifically in Bmal1-KO mice) elevates hydrogen peroxide levels and Nox4 expression in the aorta, confirming the circadian control over Nox4 gene expression and its rhythmic activity in endothelial cells.
