Publications by authors named "Ana-Irene Malo"
Patients with type 2 diabetes mellitus (T2DM) and atherogenic dyslipidemia (AD) are at higher risk of developing cardiovascular diseases (CVDs), so an interest in discovering inflammation biomarkers as indicators of processes related to CVD progression is increasing. This study aims (a) to characterize the plasma glycoprotein profile of a cohort of 504 participants, including patients with and without T2DM and/or AD and controls, and (b) to study the associations between the glycoprotein profile and other lipid and clinical variables in these populations. We characterized the plasma glycoprotein profiles by using H-NMR.
View Article and Find Full Text PDFElite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (H-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time.
View Article and Find Full Text PDFDifferential miRNA plasma profiles associated with the spontaneous loss of HIV-1 control: miR-199a-3p and its potential role as a biomarker for quick screening of elite controllers.
Clin Transl Med
July 2021
Background And Aims: Inflammation is a pathophysiological mechanism of atherosclerosis, and several mediators have been proposed as biomarkers. Acute-phase serum glycoproteins are upregulated in the liver during systemic inflammation. Because of their unique biochemical characteristics, they can be measured by H-NMR, and their role as subclinical inflammation markers is under clinical evaluation.
View Article and Find Full Text PDFBackground And Aims: Both the Nordic and Mediterranean diets claim to have a beneficial effect on lipid metabolism and cardiovascular prevention. The objective of this study was to compare diets consumed by children with FH at the time of diagnosis in Norway and Spain and to study their relationship with the lipid profile.
Methods And Results: In this cross-sectional study, we appraised the dietary intake in children (4-18 years old) with (n = 114) and without FH (n = 145) from Norway and Spain.
Article Synopsis
- Plasma glycoproteins serve as a composite biomarker for inflammation and can be analyzed through H-NMR, with this study aimed at evaluating their clinical significance in individuals living with HIV.
- A total of 221 HIV patients were assessed over 144 weeks, categorized by their CD4 T-cell counts, with specific focus on those with counts below 200 cells/µL and their responses to antiretroviral therapy.
- The study found that lower CD4 counts were associated with higher glycoprotein concentrations, and these levels not only indicated inflammation but also had predictive value for treatment responses in patients, highlighting H-NMR glycoproteins' potential in managing HIV-related inflammation.
Background And Aims: The first line of therapy in children with hypercholesterolaemia is therapeutic lifestyle changes (TLSC). The efficacy of lifestyle intervention in children with familial hypercholesterolaemia (FH), where LDL-C levels are genetically driven, deserves a focused study.
Aims: To evaluate the impact of a lifestyle education program, focused on food patterns and physical activity, on lipid profiles assessed by nuclear magnetic resonance (NMR) in children with FH vs.