Publications by authors named "Ana Yuliana"
Article Synopsis
- The study explores how endoplasmic reticulum (ER) stress affects the function of beige adipocytes, specifically their ability to regulate thermogenesis through uncoupling protein 1 expression.
- It was found that ER stress, induced by tunicamycin, significantly suppresses uncoupling protein 1 in inguinal white adipose tissue (IWAT), impacting the metabolic functions of adipocytes.
- The research identifies that ERK and JNK pathways are activated during ER stress; however, only JNK inhibition could restore the levels of peroxisome proliferator-activated receptor γ (Pparγ), which plays a crucial role in the expression of uncoupling protein 1
Browning of adipose tissue has been prescribed as a potential way to treat obesity, marked by the upregulation of uncoupling protein 1 (). Several reports have suggested that histone deacetylase (HDAC) might regulate by remodelling chromatin structure, although the mechanism remains unclear. Herein, we investigate the effect of β-adrenergic receptor (β-AR) activation on the chromatin state of beige adipocyte.
View Article and Find Full Text PDFScope: Recent reports indicate that gut microbiota and their metabolites may regulate host inflammatory conditions, including the chronic inflammation of obese adipose tissues. In this study, we investigated whether specific synthesized fatty acids, identical to the metabolites generated by gut microbiota, act as anti-inflammatory factors in obesity-induced inflammation.
Methods And Results: We first used lipopolysaccharide (LPS)-stimulated RAW 264.