Publications by authors named "Ana V Villarreal-Trevino"
Article Synopsis
- - The study investigates how genetic variations in the SLCO1B1 gene can influence the occurrence of adverse events (AEs) in pediatric patients with juvenile idiopathic arthritis (JIA) who are treated with methotrexate (MTX).
- - Researchers analyzed data from 30 JIA patients, finding that 66.7% experienced AEs, and identified that the *1B haplotype was common in this group, significantly increasing the risk of AEs.
- - The findings suggest that patients with the *1B allele may need lower doses of MTX to minimize AEs, and SLCO1B1 genotyping could help tailor treatment strategies to reduce risks during MTX therapy.
Article Synopsis
- The study aimed to investigate the epidemiology and outcomes of multisystem inflammatory syndrome in children (MIS-C) across 16 Latin American countries from August 2020 to June 2022.
- Out of 1239 children with MIS-C, the majority were previously healthy, with common symptoms including abdominal pain and conjunctival injection, and nearly half required intensive care.
- The overall death rate was 4.88%, notably higher for those not initially diagnosed with MIS-C, emphasizing the need for improved awareness and early detection of the syndrome.
Objectives: The aim of the study was to establish an international multicenter registry to collect data on patients with Multisystem Inflammatory Syndrome in Children (MIS-C), in order to highlight a relationship between clinical presentation, age of onset and geographical distribution on the clinical outcome.
Study Design: Multicenter retrospective study involving different international societies for rare immunological disorders.1009 patients diagnosed with MIS-C between March and September 2022, from 48 centers and 22 countries were collected.
Hematogenous spread of Neisseria gonorrhoeae, a sexually transmitted pathogen, results in disseminated gonococcal disease (DGD), also known as arthritis-dermatitis syndrome, due to the development of skin lesions, tenosynovitis, and arthritis. The most frequently affected population is young adults. We describe the case of an adolescent female who acutely developed skin lesions, arthritis, tenosynovitis, and constitutional symptoms.
View Article and Find Full Text PDFObjectives: To describe the design process of a medical care program for adolescents with pediatric onset rheumatic diseases (PRD) during the transition from pediatric to adult care in a resource-constrained hospital.
Methods: The model of attention was developed in three steps: 1) the selection of a multidisciplinary team, 2) the evaluation of the state of readiness of patients and caregivers for the transition, and 3) the design of a strategy of attention according to local needs. The results of the first two steps were used in order to develop the strategy of attention.
Successful Autologous Stem-Cell Transplantation Without the Use of Antithymocyte Globulin in a Patient with Refractory Systemic Juvenile Idiopathic Arthritis.
Indian J Pediatr
June 2022
Background: Patients with juvenile chronic inflammatory systemic diseases (jCID) are vulnerable to many circumstances when transitioning to adult-centered healthcare; this increases the burden of disease and worsen their quality of life.
Methods: MEDLINE, Embase, Web of Science and Scopus were searched from inception to March 16, 2021. We included observational, randomized controlled trials and quasi-experimental studies that evaluated a transitional care program for adolescents and young adults with jCIDs.
Background: Juvenile Idiopathic Arthritis (JIA) requires complex care that generate elevated costs, which results in a high economic impact for the family. The aim of this systematic review was to collect and cluster the information currently available on healthcare costs associated with JIA after the introduction of biological therapies.
Methods: We comprehensively searched in MEDLINE, EMBASE, Web of Science, Scopus, and Cochrane Databases for studies from January 2000 to March 2021.
Background: Pediatric rheumatic disease (PRD) patients and their caregivers face a number of challenges, including the consequences of the PRD in patients and the impact on multiple dimensions of the caregivers' daily lives. The objective of this study is to measure the economic, psychological and social impact that PRD has on the caregivers of Mexican children.
Methods: This is a multicenter, cross-sectional study including primary caregivers of children and adolescents with PRD (JIA, JDM and JSLE) during April and November, 2019.
Multisystem inflammatory syndrome in children (MIS-C) is an emerging entity during the coronavirus disease 2019 pandemic. Medium- and large-vessel changes are present in MIS-C; however, microcirculatory impairment has not been documented. We report a case of MIS-C in a toddler that presented with persistent fever, gastrointestinal symptoms and rash.
View Article and Find Full Text PDFDevelopment and validation of the CAREGIVERS questionnaire: multi-assessing the impact of juvenile idiopathic arthritis on caregivers.
Pediatr Rheumatol Online J
January 2020
Article Synopsis
- The study focuses on the significant role of primary caregivers for patients with Juvenile Idiopathic Arthritis (JIA), emphasizing that their experiences are influenced by social, emotional, and financial factors that impact the care relationship.
- A mixed methods approach was employed: first, qualitative interviews were conducted with caregivers to create a questionnaire, and then a quantitative phase validated this questionnaire among a larger group.
- The findings highlight nine key themes affecting caregivers, including economic strain and mental health issues, and led to a validated questionnaire that revealed high levels of depression (90%) and anxiety about the future (72%) among the participants.
Nailfold capillaroscopy (NFC) has gained remarkable interest among rheumatologists because of its utility in both clinical practice and research activity. Nevertheless, there has been scarce attention on its potential in other rheumatic disorders such as vasculitis. We perform a systematic review of literature on NFC in noninfectious vasculitides, with the aim to provide an overview of the main NFC changes described, to discuss the current evidence supporting its clinical impact and applications in daily practice and to provide future research fields.
View Article and Find Full Text PDFBackground: Kawasaki disease (KD) is one of the most common systemic vasculitis in children under 5 years of age. The epidemiology of the disease is not well established in Mexico. The objective of this study was to describe the epidemiology, clinical features and treatment of patients with KD at the Hospital Infantil de Mexico Federico Gomez (HIMFG).
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