Short-Term Creatine Supplementation May Alleviate the Malnutrition-Inflammation Score and Lean Body Mass Loss in Hemodialysis Patients: A Pilot Randomized Placebo-Controlled Trial.

Background: Creatine supplementation has been proposed to alleviate muscle loss in various populations, but has not been investigated in hemodialysis (HD) patients. Thus, our objective was to evaluate whether creatine supplementation could attenuate the loss of lean body mass (LBM) and malnutrition-inflammation score (MIS) in HD patients.

Methods: A randomized, placebo-controlled, double blind, parallel-design study included HD patients, of both sexes, aged 18-59 years.

Total protein or leucine intakes are not associated with handgrip strength in hemodialysis patients: A pilot study.

Background & Aims: Inadequate protein intake is associated with lean body mass (LBM) loss. However, it is unclear whether high protein diet and leucine intake are associated with handgrip strength (HGS), a validated marker of muscle function. This study aims to: i) assess the prevalence of patients with low HGS; and ii) verify if HGS is correlated with high protein diet and leucine consumption in hemodialysis patients.

Pre-sarcopenia in patients undergoing hemodialysis: Prevalence and association with biochemical parameters.

Background & Aims: Albumin and C reactive protein (CRP) concentrations are associated with the loss of lean body mass in the elderly. However, it remains to be ascertained whether these parameters are associated with pre-sarcopenia of chronic renal failure adult's patients undergoing replacement therapy. Therefore, we aimed to investigate the prevalence of pre-sarcopenia and it association with serum albumin and CRP concentrations in adult patients.