expression levels and related genetic polymorphisms: influence in renal cell progression and aggressive phenotypes.

Renal cell carcinoma (RCC) is the most lethal urological cancer and up to 40% of patients submitted to surgery will relapse. Thus, the study aim was to analyze the associations of SNPs with RCC patients' prognosis, and evaluate their effect on mRNA levels The rs4961280, rs3928672 and rs11996715 polymorphisms and the relative quantification of mRNA levels were analyzed by real-time PCR. We observed that genotypes carriers presented a higher cancer progression risk (odds ratio= 3.

Urachal carcinoma: A case of a rare neoplasm.

Introduction: Urachal carcinoma is a rare type of non-urothelial malignancy that arises from the urachal ligament, a remnant of fetal development. It frequently involves the dome of the bladder or its midline, with adenocarcinoma being the most common histological type. This malignancy is generally diagnosed in advanced stages and is associated with poor prognosis.

YB-1 variant and androgen receptor axis-targeted agents in metastatic castration-resistant prostate cancer patients.

To evaluate the influence of  rs10493112 variant as a genetic marker for response to second-generation androgen receptor axis-target agents. A hospital-based cohort study of 78 patients with metastatic castration-resistant prostate cancer was conducted. Genotyping was performed by TaqMan allelic discrimination technology.

Prognostic significance of positive circumferential resection margin post neoadjuvant chemotherapy in patients with esophageal or gastro-esophageal junction adenocarcinoma.

Background: The aim of the present study was to assess the prognosis of patients with esophageal or gastroesophageal junction (E/GEJ) adenocarcinoma extending beyond the muscularis propria layer (≥ypT3) and positive circumferential resection margin (CRM), post neoadjuvant chemotherapy.

Methods: 177 patients were retrospectively studied. The majority (94.

XPO5 genetic polymorphisms in cancer risk and prognosis.

miRNAs are small noncoding RNA molecules that have a very important role in gene expression regulation and, therefore, in cell homeostasis. SNPs in certain miRNA-related genes have been shown to influence cancer risk and prognosis. miRNA cellular processing is complex and involves multiple proteins.