Publications by authors named "Ana Silveira Viana"
Malignant melanoma is an aggressive and deadly form of skin cancer and novel and improved therapeutic options are needed. A promising strategy involves the use of metallodrugs combined with liposomes for targeted delivery to cancer cells. In this work, a family of iron(III) complexes was synthesized bearing a trianionic aminobisphenolate ligand (L) and phenanthroline-type co-ligands (NN).
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- Lipidic implants are effective for controlled drug delivery with good biocompatibility, but they often have rigid drug release profiles that limit their effectiveness.
- Researchers developed lipidic implants containing caffeine, salicylic acid, and rutin, experimenting with different materials like Gelucire 50/02, sucrose, and biobased ionic liquids (ILs) to enhance drug release.
- The findings indicated that ILs, particularly [Cho][Glu], significantly improved drug incorporation and release profiles, making them promising options for improving lipid-based drug delivery systems.
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- L. () is a medicinal shrub from Europe and western Asia that's gaining interest for its bioactive compounds.
- The study focused on creating a topical extract formulation using ethosomes, which were developed through an ultrasound-assisted method.
- Results showed the ethosomes had good size and stability, a high extract entrapment capacity, and beneficial effects like collagenase inhibition and good skin compatibility, suggesting potential in skin care applications.
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- Insulin is a peptide hormone that plays a crucial role in wound healing, but it needs protection from the environment, which can be achieved through polymer-based nanoparticles.
- This study focuses on creating and characterizing insulin-loaded PLGA nanoparticles for topical wound treatment, which have a mean size of about 500 nm and maintain their spherical shape.
- Analyses show that insulin retains its structural integrity after encapsulation, and the formulation demonstrates controlled release and promising safety results in both cell lines and preliminary in vivo tests.
Further Evidence of Possible Therapeutic Uses of L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations.
Pharmaceutics
December 2020
L. is widely used in traditional medicine with different applications. However, confirmative studies are strongly required.
View Article and Find Full Text PDFCancer like melanoma is a complex disease, for which standard therapies have significant adverse side effects that in most cases are ineffective and highly unspecific. Thus, a new paradigm has come with the need of achieving alternative (less invasive) and effective therapies. In this work, biocompatible gold nanoparticles (GNPs) coated with hyaluronic acid and oleic acid were prepared and characterized in terms of size, morphology and cytotoxicity in the presence of , and two cell lines, the keratinocytes (healthy skin cells, HaCat) and the melanoma cells (B16F10).
View Article and Find Full Text PDFHyaluronic acid (HA) is commonly used through intra-articular administration for viscosupplementation in osteoarthritis and other disorders. HA is generally supplied as an injection commonly reported as painful, with strong limitations after treatment. In this study, an alternative delivery system was constructed based on HA hydrogel and poly(lactic-co-glycolic acid) (PLGA) particles with oleic acid.
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