Effect of curcumin and three analogues on pre-osteoblast cells' viability, differentiation, and gene expression.

Curcumin, found in turmeric rhizomes (Curcuma longa L.), has been widely studied for its potential health benefits, including anti-inflammatory, antioxidant, and wound-healing properties. However, due to its low bioavailability and unfavorable pharmacokinetics, analogous compounds have been developed to obtain better biopharmaceutical characteristics and enhanced biological effects.

Validity and reliability of the modified sphygmomanometer test for assessing upper limb and trunk muscle strength in adolescents.

The Modified Sphygmomanometer Test (MST) is a method for assessing muscle strength that offers objective measures similar to those of a portable dynamometer, while also being cost-effective. However, previous studies have not investigated the measurement properties of the MST in adolescents. Thus, the objectives of the study were (1) to examine the concurrent criterion validity, test-retest and interrater reliability of the Modified Sphygmomanometer Test (TMS) for assessing muscle strength in adolescents, (2) to calculate the Standard Error of Measurement (EPM) and the smallest real difference (SRD) of muscle strength values; and (3) analyze the different forms of operationalization and their influence on the results obtained.

Improving accuracy of GPT-3/4 results on biomedical data using a retrieval-augmented language model.

Large language models (LLMs) have made a significant impact on the fields of general artificial intelligence. General purpose LLMs exhibit strong logic and reasoning skills and general world knowledge but can sometimes generate misleading results when prompted on specific subject areas. LLMs trained with domain-specific knowledge can reduce the generation of misleading information (i.

Corrigendum: Comparison of 3DCRT and IMRT out-of-field doses in pediatric patients using Monte Carlo simulations with treatment planning system calculations and measurements.

[This corrects the article DOI: 10.3389/fonc.2022.

Lack of knowledge about the human papillomavirus vaccine among Brazilian adolescents: A cross-sectional study.

To analyze the distribution and factors associated with lack of knowledge about the human papillomavirus (HPV) vaccine among Brazilian adolescents.Cross-sectional study using the 2019 National School Health Survey among 17,805 Brazilian students of public and private schools, aged 13-17 years. The outcome variable was "lack of knowledge about the HPV vaccine" and the explanatory variables were sociodemographic, behaviors, knowledge, and health conditions.

Expression of HOXA10 and HOXA11 in the endometrium of infertile patients with chronic endometritis.

Objective: The study aimed to evaluate the impact of CE on the expression of HOXA10 and HOXA11 during the late proliferative phase in the endometrium of infertile women.

Methods: A prospective, translational cohort study was conducted in partnership with the Hospital Universitário Antônio Pedro in Niterói and the Clínica Ginendo in Rio de Janeiro after approval by the Ethics Committee. The patients were selected to participate in the study after showing an indication for hysteroscopy.

Involvement of GPR43 Receptor in Effect of on Murine Steroid Resistant Chronic Obstructive Pulmonary Disease: Relevance to Pro-Inflammatory Mediators and Oxidative Stress in Human Macrophages.

Background: Cytokine storm and oxidative stress are present in chronic obstructive pulmonary disease (COPD). Individuals with COPD present high levels of NF-κB-associated cytokines and pro-oxidant agents as well as low levels of Nrf2-associated antioxidants. This condition creates a steroid-resistant inflammatory microenvironment.

Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E cells.

Increasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs prepared by emulsification or nanoprecipitation presented 74 or 200 nm, and association efficiency (AE) of 68 % and 17 %, respectively, and a rapid burst release of VitD3.

Fahr Syndrome: When Dysarthria Doesn't Mean a Stroke.

Fahr syndrome is a rare neurodegenerative disorder, characterized by calcium deposition in the brain. It is usually associated with phosphocalcium metabolism disorders, like hypoparathyroidism, or with genetical predisposition, as seen in Fahr disease. Given the wide array of differential diagnoses medical awareness should be emphasized to prompt diagnosis and management.

Prevalence and factors associated with possible cases of familial hypercholesterolemia in Brazilian adults: a cross-sectional study.

This study aimed to estimate the prevalence of possible cases of FH and analyze associated factors in the adult Brazilian population. Cross-sectional study with laboratory data from the Brazilian National Health Survey, with 8521 participants. Possible cases of FH were defined according to the Dutch Lipid Clinic Network criteria.

Corrigendum: Comparison of 3DCRT and IMRT out-of-field doses in pediatric patients using Monte Carlo simulations with treatment planning system calculations and measurements.

[This corrects the article DOI: 10.3389/fonc.2022.

Temporal and spatial distribution trends of polio vaccine coverage in less than one-year old children in Brazil, 2011-2021.

Background: Low polio vaccine coverage can result in the spread of Poliovirus to areas free from viral circulation. This study analyzed the temporal trends and spatial distribution of polio vaccine coverage in one year-old children in Brazil, between 2011 and 2021.

Methods: This was an ecological, time-series study (2011 to 2021) with annual vaccine coverages against poliomyelitis, extracted from the Information System of the National Immunization Program from the 26 States and the Distrito Federal (DF).

Anaerobic adhesives effect on counter-torque of abutment screws on implants with external hexagon and conical connections: An in vitro study.

Background: Abutment screw loosening is a common complication of implant supported prostheses, especially for single crowns. In engineering, anaerobic adhesives (AA) are used to provide chemical locking between screw surfaces, but their application in implantology remains unclear.

Purpose: The purpose of this article is to evaluate, in vitro, the effect of AA on counter-torque of abutment screws for cemented prosthesis on dental implants with external hexagon connection (EHC) and conical connection (CC).

Blood count reference intervals for the Brazilian adult population: National Health Survey.

Objective: To estimate the reference intervals (RIs) of complete blood count parameters in the Brazilian adult population.

Methods: Cross-sectional study, with data from the National Health Survey (Pesquisa Nacional de Saúde - PNS), between 2014-2015. The final sample consisted of 2,803 adults.

Differences between reference intervals of blood counts of Brazilian adults with and without sickle cell trait according to laboratory tests from the National Health Survey.

Objective: To compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT).

Methods: Cross-sectional study, based on the National Health Survey, 2014-2015, composed of 8,952 individuals. The sample of patients with SCT was composed of 234 adults.

Environmental heterogeneity of a tropical river-to-sea continuum and its relationship with structure and phytoplankton dynamics - Lençóis Maranhenses National Park.

β-diversity and functional traits of phytoplankton indicators associated with environmental heterogeneity were investigated as environmental quality descriptors in coastal (CS), estuarine (ES), and limnetic (LS) sectors in a tropical river-to-sea ecosystem. Results showed that environmental heterogeneity was marked by spatial differences, contributing to biological heterogeneity. Sporadic and recurrent blooms were associated with environmental spatiotemporal variations and reflected a reduction in ES α-diversity.

Vaccination against human papillomavirus in Brazilian schoolchildren: National Survey of School Health, 2019.

Objective: to analyze the prevalence of schoolchildren vaccinated against human papillomavirus (HPV) and the reasons related to non-vaccination.

Method: cross-sectional study, with data from the 2019 National Survey of School Health. The sample consisted of 160,721 students aged 13 to 17 years.

Prediction of Noninvasive Ventilation Failure in COVID-19 Patients: When Shall We Stop?

Introduction: In coronavirus disease 2019 (COVID-19), there are no tools available for the difficult task of recognizing which patients do not benefit from maintaining respiratory support, such as noninvasive ventilation (NIV). Identifying treatment failure is crucial to provide the best possible care and optimizing resources. Therefore, this study aimed to build a model that predicts NIV failure in patients who did not progress to invasive mechanical ventilation (IMV).

Pathogenic , spp. and spp. in Two Natural Conservation Centers of Wildlife in Portugal: Genotypic and Phenotypic Characterization.

Human-wildlife coexistence may increase the potential risk of direct transmission of emergent or re-emergent zoonotic pathogens to humans. Intending to assess the occurrence of three important foodborne pathogens in wild animals of two wildlife conservation centers in Portugal, we investigated 132 fecal samples for the presence of (Shiga toxin-producing (STEC) and non-STEC), spp. and spp.

Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy.

The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial. Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial organoids and evaluate the biological, functional and clinical significance of the IL-22 mediated pathways in ulcerative colitis (UC). We show that IL-22 regulated pro-inflammatory pathways are involved in microbial recognition, cancer and immune cell chemotaxis; most prominently those involving CXCR2 neutrophils.

Chemotherapy-Induced Dysgeusia and Its Perverse Consequences: A Case Report.

Dysgeusia is one of the most common side effects of chemotherapy. Still, there is little information given to patients and limited knowledge about its diagnosis and management. We report the case of a patient under a standard regimen of adjuvant chemotherapy treatment (cisplatin and vinorelbine) who developed a life-threatening case of diabetes mellitus decompensation (hyperosmolar hyperglycemic state) resulting from extreme dietary intake due to severe dysgeusia and polydipsia.

Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour.

ATRX is a chromatin remodeller that maintains telomere homeostasis. Loss of is described in approximately 10% of pancreatic neuroendocrine tumours (PanNETs) and associated with poorer prognostic features. Here, we present a genetically engineered mouse model (GEMM) addressing the role of loss () in pancreatic β cells, evaluating a large cohort of ageing mice (for up to 24 months (mo.

Comparison of 3DCRT and IMRT out-of-field doses in pediatric patients using Monte Carlo simulations with treatment planning system calculations and measurements.

Unlabelled: 3DCRT and IMRT out-of-field doses in pediatric patients were compared using Monte Carlo simulations with treatment planning system calculations and measurements.

Purpose: Out-of-field doses are given to healthy tissues, which may allow the development of second tumors. The use of IMRT in pediatric patients has been discussed, as it leads to a "bath" of low doses to large volumes of out-of-field organs and tissues.