Social representations of breastfeeding in health science students: A first step to strengthening their training.

Aim: This study aims to describe the social representations of breastfeeding among Mexican health science students.

Background: Breastfeeding is a complex phenomenon involving biological, affective and sociocultural aspects. Its definition includes diverse beliefs, attitudes, traditions and myths.

Chemotherapy and Immune Checkpoint Blockade for Gastric and Gastroesophageal Junction Adenocarcinoma.

Importance: Combining immune checkpoint blockade (ICB) with chemotherapy improves outcomes in patients with metastatic gastric and gastroesophageal junction (G/GEJ) adenocarcinoma; however, whether this combination has activity in the perioperative setting remains unknown.

Objective: To evaluate the safety and preliminary activity of perioperative chemotherapy and ICB followed by maintenance ICB in resectable G/GEJ adenocarcinoma.

Design, Setting, And Participants: This investigator-initiated, multicenter, open-label, single-stage, phase 2 nonrandomized controlled trial screened 49 patients and enrolled 36 patients with resectable G/GEJ adenocarcinoma from February 10, 2017, to June 17, 2021, with a median (range) follow-up of 35.

The meteorological contrast index in the context of climate change and public health.

In the context of climate change, extreme weather events and sudden shifts in weather patterns are becoming increasingly frequent. The atmosphere is considered a source of meteorological and climatic risks for human beings and living organisms. Numerous studies have examined the correlation between meteorological variables and human morbidity and mortality.

High sensitivity determination of mineral oils and olefin oligomers in cocoa powder and related packaging: Method validation and market survey.

Mineral oil saturated (MOSH) and aromatic hydrocarbons (MOAH) and related hydrocarbons of synthetic origin are both packaging and processing contaminants of health concerns. The purpose of this work was to validate a method for their rapid and high-sensitivity determination in cocoa powder, using it to monitor the presence of these contaminants in products purchased in Italy and North Macedonia. Relevant primary and secondary packaging was also analyzed.

Autologous regeneration of blood vessels in urinary bladder matrices provides early perfusion after transplant to the bladder.

Large animal testing and clinical trials using bioengineered bladder for augmentation have revealed that large grafts fail due to insufficient blood supply. To address this critical issue, an in vivo staged implant strategy was developed and evaluated to create autologous, vascularized bioengineered bladder tissue with potential for clinical translation. Pig bladders were used to create acellular urinary bladder matrices (UBMs), which were implanted on the rectus abdominus muscles of rats and pigs to generate cellular and vascular grafts.

Paradoxical Stimulatory Response of Remanent Sphincter of Oddi to Buscapina After Endoscopic Sphincterotomy.

Background/aims: Endoscopic removal of bile duct stones has become the treatment of choice, which includes endoscopic sphincterotomy (EST) in the majority of cases, destroying at least partially the Oddi sphincter (OS). Loss of sphincter function in variable grade has been described, but changes in innervation are not known.

Methods: Endoscopic manometry of OS was performed in 14 patients after EST with specialized perfused catheter.

A micro-extrusion 3D printing platform for fabrication of orodispersible printlets for pediatric use.

3D printed pharmaceuticals offers the potential to manufacture personalized medicines for patients. Such technology is of particular benefit to pediatric populations from the offer of increased patient compliance and dose flexibility. With a bench-to-patient approach, this study established and optimized the critical parameters of the semi-solid micro-extrusion 3D printing process to guarantee the quality attributes of the final dosage form.

Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment.

Aim: Mucositis, linked to methotrexate, daunorubicin or cyclophosphamide, is a frequent childhood acute lymphoblastic leukemia (ALL) therapy side effect. miRNAs regulate the expression of pharmacokinetic/pharmacodynamic pathway genes. SNPs in miRNAs could affect their levels or function, and affect their pharmacokinetic/pharmacodynamic pathway target genes.

Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing.

Human ageing is associated with a gradual decline in the physiological functions of the body at multiple levels and it is a key risk factor for many diseases, including cancer. Ageing process is intimately related to widespread cellular senescence, characterised by an irreversible loss of proliferative capacity and altered functioning associated with telomere attrition, accumulation of DNA damage and compromised mitochondrial and metabolic function. Tumour and senescent cells may be generated in response to the same stimuli, where either cellular senescence or transformation would constitute two opposite outcomes of the same degenerative process.

Emergency response time after out-of-hospital cardiac arrest.

Objectives: To investigate the emergency response time after out-of-hospital cardiac arrest (OHCA) in four cities in Serbia.

Methods: A prospective, two-year, multicenter study was designed. Using the Utstein template we recorded out-of-hospital CPR (OHCPR) and analyzed the time sequence segment of the variables in OHCA and CPR gold standards.

Seasonal distribution of Alternaria, Aspergillus, Cladosporium and Penicillium species isolated in homes of fungal allergic patients.

Background: Allergy to airborne fungi can cause rhinitis and severe asthma, hence the exposure to spores inside home is an important factor of sensitization. The aim of this study was to determine the distribution and prevalence of species of Alternaria, Aspergillus, Cladosporium and Penicillium inside and outside of homes of patients allergic to fungi and to evaluate seasonal variations.

Methods: Air samples were collected in 22 selected homes of patients with allergy to fungi using a volumetric method of impacting plates with culture media.

The upper airway and obstructive sleep apnea in morbidly obese women.

Study Objectives: We are currently carrying out a study on the changes of the upper airway in morbidly obese women and the relationship of the upper airway with the severity of obstructive sleep apnea syndrome (OSAS). This study is similar to the study by Fogel RB et al, which appeared in Sleep 2003;2:150-5.

Design: Patients underwent a cardiorespiratory polygraphic sleep study, respiratory function test (spirometry, plethysmography, arterial blood gas analysis), and computed tomographic studies of the upper airway.