Kinematical and Physiological Responses of Overground Running Gait Pattern at Different Intensities.

Runners achieve forward locomotion through diverse techniques. However, understanding the behavior of the involved kinematical variables remains incomplete, particularly when running overground and along an intensity spectrum. We aimed to characterize the biomechanical and physiological adaptations while running at low, moderate, heavy and severe intensities.

Effect of the Fran CrossFit Workout on Oxygen Uptake Kinetics, Energetics, and Postexercise Muscle Function in Trained CrossFitters.

Purpose: Fran is one of the most popular CrossFit benchmark workouts used to control CrossFitters' improvements. Detailed physiological characterization of Fran is needed for a more specific evaluation of CrossFitters' training performance improvements. The aim of the study was to analyze the oxygen uptake (V˙O2) kinetics and characterize the energy system contributions and the degree of postexercise fatigue of the unbroken Fran.

Swimming sprint performance depends on upper/lower limbs strength and swimmers level.

Swimming performance is likely influenced by strength, but differences between butterfly, backstroke, breaststroke and front crawl, as well as between novice and expert swimmers, are unclear. We have examined the associations between sprint performances, upper and lower limb strength, and anthropometric characteristics in 14 (six males and eight females) non-elite and 16 (nine males and seven females) elite-level swimmers. After an anthropometric characterisation, participants performed four 25 m maximal swims (one per technique) with 10 min intervals, right and left shoulder flexion/extension isokinetic testing at 90 and 300º/s angular velocities and three countermovement jumps.

Physical Fitness Profile of High-Level Female Portuguese Handball Players.

We characterized the physical and physiological profiles of high-level female Portuguese handball players and examined the relationships between their anthropometric characteristics, general motor performance and cardiopulmonary fitness. Twenty-four high-level female handball players with an average age of 23.6 ± 5.

Acute ventilatory responses to swimming at increasing intensities.

Background: Physical exercise is a source of stress to the human body, triggering different ventilatory responses through different regulatory mechanisms and the aquatic environment imposes several restrictions to the swimmer, particularly regarding the restricted ventilation. Thus, we aimed to assess the acute ventilatory responses and to characterize the adopted breathing patterns when swimming front crawl at increasing intensity domains.

Methods: Eighteen well-trained swimmers performed 7 × 200 m front crawl (0.

Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient.

Unlabelled: Early malignant syphilis is an uncommon form of secondary syphilis and characterized by pleomorphic multiple round-to-oval papules, some with necrosis, and associated with systemic signs and symptoms. Usually seen in immunosuppressed patients, mainly those infected with HIV, it can also be observed in immunocompetent patients. We report a case in a young healthy woman with the characteristic features of the disease and with favourable skin lesion evolution after appropriate treatment with penicillin.

Shoulder Torque Production and Muscular Balance after Long and Short Tennis Points.

Tennis is an asymmetric sport characterized by a systematic repetition of specific movements that may cause disturbances in muscular strength, power, and torque. Thus, we assessed (i) the torque, power, ratio production, and bilateral asymmetries in the shoulder's external and internal rotations at 90 and 180°/s angular velocities, and (ii) the point duration influence of the above-mentioned variables. Twenty competitive tennis players performed external and internal shoulder rotations; an isokinetic evaluation was conducted of the dominant and non-dominant upper limbs before and after five and ten forehands.

Mechanics and Energetic Analysis of Rowing with Big Blades with Randall Foils.

Empirical observations support that the addition of a plastic strip - also known as Randall foils - on the top edge of a rowing blade improves rowing efficiency during the cycle propulsive phase. The aim of the current study was to analyze the effect of using big blades with and without Randall foils on rowing performance. Twenty experienced rowers performed two 90 s tethered rowing bouts (with and without Randall foils) to assess their impact on force production and physiologic variables.

Repeatability of ventilatory, metabolic and biomechanical responses to an intermittent incremental swimming protocol.

. This study aimed to determine the repeatability of ventilatory, metabolic and biomechanical variables assessed at a large spectrum of front crawl swimming intensities. We hypothesized a strong agreement (combined with a small range of variation) between a typical step protocol performed in two experimental moments.

Effects of Wearing a 50% Lower Jaw Advancement Splint on Biophysical and Perceptual Responses at Low to Severe Running Intensities.

Acute ergogenic effects of wearing occlusal splints have been reported for aerobic and anaerobic exercises, but the literature centered on performance improvement by using jaw repositioning splints is scarce. We aimed to analyze the effect of wearing a 50% lower jaw advancement splint on biophysical and perceptual responses at low to severe running intensities. Sixteen middle- and long-distance runners performed twice a 7 × 800 m intermittent running protocol (with 1 km·h increments and 30 s rest periods) in an outdoor track field using two lower intraoral splints (a placebo and a lower jaw advancer).

Post-swim oxygen consumption: assessment methodologies and kinetics analysis.

Objective: This study aimed at comparing different recovery-based methods to assess the highest exercise oxygen uptake value ([Formula: see text]Opeak) when swimming at low-moderate, heavy and severe intensities. Complementarily, the different recovery curve kinetics were analysed.

Approach: Eighteen competitive swimmers performed a 5 × 200 m front crawl intermittent protocol (0.

Primary Aortoesophageal Fistula: Is a High Level of Suspicion Enough?

Unlabelled: Aortoenteric fistula (AEF) is a rare condition with a high mortality rate. AEFs are classified according to their primary and secondary causes, the former being less frequent. Primary AEFs occur in a native aorta and their causes include aneurysms, foreign bodies, tumours, radiotherapy and infection.

Physiological and Biomechanical Evaluation of a Training Macrocycle in Children Swimmers.

Physiological responses related to 400-m front crawl performance were examined in a 11-week training macrocycle in children 11.6 ± 1.2 years old.

Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines.

In this research work we report the synthesis of a new series of triazene prodrugs designed for Melanocyte-Directed Enzyme Prodrug Therapy (MDEPT). These compounds are derived from the N-acyltyrosine amino acid - a good enzyme substrate for the tyrosinase enzyme, which is significantly overexpressed in melanoma cells. We analysed their chemical stability and plasma enzymatic hydrolysis, and we also evaluated the release of the antitumoral drug in the presence of the tyrosinase.

Extensive chordate and annelid macrosynteny reveals ancestral homeobox gene organization.

Genes with the homeobox motif are crucial in developmental biology and widely implicated in the evolution of development. The Antennapedia (ANTP)-class is one of the two major classes of animal homeobox genes, and includes the Hox genes, renowned for their role in patterning the anterior-posterior axis of animals. The origin and evolution of the ANTP-class genes are a matter of some debate.

Hox genes are not always Colinear.

The deuterostomes are the clade of animals for which we have the most detailed understanding of Hox cluster organisation. With the Hox cluster of amphioxus (Branchiostoma floridae) we have the best prototypical, least derived Hox cluster for the group, whilst the urochordates present us with some of the most highly derived and disintegrated clusters. Combined with the detailed mechanistic understanding of vertebrate Hox regulation, the deuterostomes provide much of the most useful data for understanding Hox cluster evolution.