Reducing perinatal HIV transmission among HIV-infected pregnant women.

Background: In 1995, Help Understand and Guide-Me (HUG-Me) began planning the implementation of Protocol 076, a treatment that aids in the reduction of perinatal transmission of human immunodeficiency virus (HIV). A program coordinator and a social worker worked with a 1572 bed-hospital system to successfully implement the protocol.

Methods: Program effectiveness was tracked through monitoring of client outcomes.

Protease inhibitor use in 233 pregnancies.

Background: In the United States, as most highly active antiretroviral therapy (HAART) regimens used during pregnancy in HIV-infected women include a protease inhibitor (PI), it is important to determine the effects of PIs specifically rather than all HAART regimens. Prospective trials employing HAART during pregnancy are ongoing.

Objective: To better understand the effects of PI use during pregnancy on prematurity, maternal and infant adverse events, and infant outcomes.