Publications by authors named "Ana Romero Lluch"

Article Synopsis
  • This study analyzed characteristics, survival rates, and prognostic factors in 133 patients with bone metastases from differentiated thyroid carcinoma over a follow-up period of 40 months.
  • It found that the survival rates were 53.5% at 3 years, 39.5% at 5 years, and 28.5% at 10 years, with significant factors affecting survival including age, lymph node metastases, and treatment with I131.
  • The research highlighted that patients treated with I131 had better outcomes, while older age and lymph node involvement were linked to increased mortality.
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Article Synopsis
  • - The study analyzed 202 patients with head and neck paragangliomas (HN-PGL) across 16 Spanish hospitals, noting that 67.8% of participants were women, with a mean age of 53.1 years and 264 tumors examined, primarily located in the carotid body.
  • - Among patients, 20.8% had multiple tumors and 4% had metastatic disease; genetic testing revealed a pathogenic variant in SDHx in half of those tested, which was linked to younger patients and more complex tumor profiles.
  • - The results showed that while surgery was the most common treatment, radiotherapy and observation (monitoring without active treatment) were also effective, and long-term survival rates remained high
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  • The study aimed to identify patients with chronic hypoparathyroidism who either had adequate (AC) or not adequately controlled (NAC) disease, as poor control is linked to complications and increased mortality.
  • Researchers analyzed data from 337 patients across 16 Spanish hospitals to assess disease control through biochemical criteria and clinical wellness, finding that many patients were not adequately controlled.
  • Findings revealed that 45.9% to 63.1% of patients met the NAC criteria, with those who had dyslipidemia being at a greater risk, and NAC patients exhibited higher rates of associated comorbidities like chronic kidney disease and eye disorders compared to AC patients.
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Purpose: Population-based and registry studies have shown that chronic hypoparathyroidism is accompanied by long-term complications. We aimed to evaluate the risk of incident comorbidity among patients with chronic postsurgical hypoparathyroidism in real-life clinical practice in Spain.

Methods: We performed a multicenter, retrospective cohort study including patients with chronic postsurgical hypoparathyroidism lasting ≥3 years with at least a follow-up visit between January 1, 2022 and September 15, 2023 (group H).

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Objective: The aim of this study is to describe the characteristics, survival and prognostic factors of a cohort of patients with bone metastases (BMs) from differentiated thyroid carcinoma (DTC).

Methods: This was a multicenter retrospective observational study including patients diagnosed with BMs from DTC between 1980 and 2021. A Cox regression was performed to study prognostic factors for 5- and 10-year survival.

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Objective: There is hardly any information on the consumption of healthcare resources by older people with differentiated thyroid cancer (DTC). We analyzed these consumptions in older patients with DTC and compared patients 75 years and older with subjects aged 60-74 years.

Methods: A multicenter, retrospective analysis was designed.

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Article Synopsis
  • The study aimed to analyze how the age at which patients are diagnosed with differentiated thyroid carcinoma (DTC) affects their risk of disease progression and mortality after initial treatment, focusing on patients over 60 years old.
  • Researchers compared two age groups: elderly (60-74 years) and very old (75 years and older) among 1,668 patients, finding that older patients generally had larger tumors, more vascular invasion, and lower rates of lymphocytic thyroiditis.
  • The results indicated that while older age correlates with lower overall survival, very old patients do not face an increased risk of structural disease compared to their younger counterparts throughout the follow-up period.
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Introduction: Hypoparathyroidism (HP) is the most common complication of total thyroidectomy and can be an emergency.

Objectives: To describe the prevalence of HP after total thyroidectomy in children under 14 years of age, the variables related to its appearance and its clinical expression.

Patients And Methods: Retrospective study at a children's hospital in the last 20 years.

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Introduction: Immune checkpoint inhibitors (ICPI) have improved progression-free survival in several solid tumors. Side effects are related to overstimulation of the immune system. Thyroid dysfunction (TD) is the most common endocrine immune-related adverse event of ICPI.

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Objective: We aimed to study the predictive factors for recovery of parathyroid function in hypoparathyroid patients after total thyroidectomy for thyroid cancer.

Methods: We designed a retrospective, multicentre and nation-wide analysis of patients with total thyroidectomy who were seen in twenty endocrinology departments from January to March 2018. We selected patients with histologically proven thyroid cancer and retrieved information related to surgical procedure and thyroid cancer features.

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The clinical characteristics of patients with postoperative hypoparathyroidism who recover parathyroid function more than 12 months after surgery have not been studied. We aimed to evaluate whether the intensity of replacement therapy with calcium and calcitriol is related to the late recovery of parathyroid function. We compared the demographic, surgical, pathological, and analytical features of two groups of patients: cases, i.

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Introduction: Hypoparathyroidism (HP) is the most common complication of total thyroidectomy and can be an emergency.

Objectives: To describe the prevalence of HP after total thyroidectomy in children under 14 years of age, the variables related to its appearance and its clinical expression.

Patients And Methods: Retrospective study at a children's hospital in the last 20 years.

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Background: Total thyroidectomy is the standard initial surgery for differentiated thyroid carcinoma (DTC), but the extent of the thyroidectomy remains controversial. Thyroid lobectomy (TL) has been widely used in eastern countries; however, its use has not been generalized in western countries, including Spain. Our aims were to analyse the clinical outcome of a multicentre nation-wide cohort of DTC patients treated by TL and to assess the proportion of patients who required completion of the thyroidectomy and who presented disease recurrence.

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Background: Recent guidelines for the treatment of hypoparathyroidism emphasize the need for long-term disease control, avoiding symptoms and hypocalcaemia. Our aim has been to analyze the prevalence of poor disease control in a national cohort of patients with hypoparathyroidism, as well as to evaluate predictive variables of inadequate disease control.

Methods: From a nation-wide observational study including a cohort of 1792 patients undergoing total thyroidectomy, we selected 260 subjects [207 women and 53 men, aged (mean ± SD) 47.

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Introduction: Thyroid nodules are a common finding. A high-resolution thyroid nodule clinic (HR-TNC) condenses all tests required for the evaluation of thyroid nodules into a single appointment. We aimed to evaluate the clinical outcomes at HR-TNCs.

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Purpose: The prevalence of postoperative hypoparathyroidism has been studied in registries and in surgical series with highly variable and imprecise results. However, the frequency of this hormonal deficiency in the clinical practice of endocrinologists is not known with accuracy. We aimed to assess the prevalence and risk factors of hypoparathyroidism in patients undergoing total thyroidectomy in Spain.

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Purpose: This study sought to evaluate and compare the utility of 18-F-fluorodihydroxyphenylalanine (F-DOPA) and 18-F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for identification of lesions in patients with recurrent medullary thyroid carcinoma (MTC). In addition, we analyzed the correlation between the calcitonin (Ct), carcinoembryonic antigen (CEA) levels, each doubling time (DT), and PET positivity. We evaluated the reliability of the 150 pg/mL Ct cutoff set by the American Thyroid Association guidelines for further imaging (including F-DOPA PET/CT).

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Purpose: To determine the impact of Laparoscopic Sleeve Gastrectomy (LSG) on the resolution of type 2 diabetes (T2DM) and Prediabetes (PDM) in obese patients, as well as potential improvements in other comorbidities.

Material And Methods: Observational retrospective study. We studied all patients with T2DM (n= 36) or PDM (n= 44) who underwent LSG in our hospital between years 2009 and 2012.

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Introduction: Sellar masses are an heterogeneous group of lesions, both in nature and management. Not all of them require surgery.

Objectives: To describe the presenting symptoms of sellar masses and endocrine abnormalities occurring during follow-up.

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Few effective therapeutic tools are currently available to fight the increasing prevalence of obesity and its associated comorbidities. Bariatric surgery is the only treatment with proven long-term effectiveness, but is associated to a high surgical risk and significant economic costs because of its technical complexity and the characteristics of patients. This is leading to development of new endoscopic procedures with less clinical risks and economic costs, while maintaining the benefits in terms of morbidity and mortality, which could even serve as a bridging element before surgery in cases where this is unavoidable, allowing for preoperative weight loss and control of comorbidities in order to improve anesthetic risks and possible complications.

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