Difficult-to-Treat Infections in Critically Ill Patients: A Comprehensive Review and Treatment Proposal.

The management of infections caused by difficult-to-treat in critically ill patients poses a significant challenge. Optimal antibiotic therapy is crucial for patient prognosis, yet the numerous resistance mechanisms of , which may even combine, complicate the selection of an appropriate antibiotic. In this review, we examine the epidemiology, resistance mechanisms, risk factors, and available and future therapeutic options, as well as strategies for treatment optimization.

Cost-Utility Analysis of PCSK9 Inhibitors and Quality of Life: A Two-Year Multicenter Non-Randomized Study.

The primary objective of this study was to conduct a cost-utility analysis of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in real-world, comparing their use with standard care for managing cardiovascular disease. A multicenter prospective study was conducted across 12 Spanish hospitals from May 2020 to April 2022, involving 158 patients with hypercholesterolemia or atherosclerotic cardiovascular disease. This study assessed health-related quality of life (QoL) using the EQ-5D-3L questionnaire.

Cognitive Function with PCSK9 Inhibitors: A 24-Month Follow-Up Observational Prospective Study in the Real World-MEMOGAL Study.

Introduction: The cognitive safety of monoclonal antibody proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) has been established in clinical trials, but not yet in real-world observational studies. We assessed the cognitive function in patients initiating PCSK9i, and differences in cognitive function domains, to analyze subgroups by the low-density lipoprotein cholesterol (LDL-C) achieved, and differences between alirocumab and evolocumab.

Methods: This has a multicenter, quasi-experimental design carried out in 12 Spanish hospitals from May 2020 to February 2023.

[Surgical jejunostomy as digestive tube access in the long-term].

Home enteral nutrition (HEN) is the choice for patients who can not mantain oral intake but have a functioning gastrointestinal tract when it isn't justify keeping the patient in the hospital. The results of the HEN registry of the NADYA group in 2010 shows information related to the enteral acces route: 51% of the cases used nasogastric tubes, 27% gastrostomies, 10% oral route and 3% jejunostomies. Placement of a needle catheter jejunostomy is recommended for candidates for enteral nutrition undergoing major abdominal surgery, but publications about long-term use of this acces are scarce.