Publications by authors named "Ana Rita Coelho"
Article Synopsis
- Acute generalized exanthematous pustulosis (AGEP) is a serious skin reaction often triggered by medications, though it can sometimes result from infections.
- While there have been reports linking AGEP to COVID-19, most cases involve drug usage rather than the virus directly.
- This case study highlights a 64-year-old woman with AGEP connected to COVID-19, who had no prior use of any offending drugs.
Introduction: In locally advanced rectal cancers (LARC), tumour node metastasis (TNM) staging is far from optimal. The authors aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis.
Methods: Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres.
Rifampicin-Induced Nephrotoxicity in a Tuberculosis Patient: Treatment Dilemma?
Eur J Case Rep Intern Med
October 2021
Unlabelled: Acute kidney injury related to rifampin is usually a clinical diagnosis. We report a case of a man being treated for pulmonary tuberculosis with acute tubulointerstitial nephritis related to rifampicin.
Learning Points: Rifampicin can cause acute kidney injury.
To investigate the value of previously described pretreatment hematological and biochemical biomarkers as predictors of pathological response. The authors performed a retrospective analysis of 191 patients with locally advanced rectal cancer who underwent long-course neoadjuvant chemoradiotherapy at two Portuguese centers. The authors performed logistic regression analysis to search for predictive markers of pathological complete and good response.
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- A new voltammetric biosensor is developed to detect cyanide by utilizing its inhibitory effect on the enzyme cytochrome c nitrite reductase (ccNiR).
- The biosensor was created using commercial graphite pencil leads for electrodes and demonstrated a reliable response to varying cyanide concentrations, with a detection range of 5-76 μM for cyclic voltammetry.
- This innovative use of pencil leads as electrodes shows promise for affordable, on-site monitoring of cyanide levels in aquatic environments.
Article Synopsis
- Leydig cell tumors are uncommon tumors found in the ovaries.
- Patients often show symptoms like missed periods (amenorrhea or oligomenorrhea) and signs of increasing male characteristics (virilization).
- High testosterone levels from these tumors can lead to an increase in red blood cell count (erythrocytosis).
Article Synopsis
- HIV patients on antiretroviral therapy have increased risks for diabetes, but the best diagnostic approach for identifying diabetes in these patients is still debated due to differing results from various tests.
- A study involving 220 HIV-infected individuals compared fasting glucose, OGTT, and HbA1c to determine the prevalence of prediabetes and diabetes, finding discrepancies in diagnosis rates across methods.
- Results indicated no diabetes cases via HbA1c, with OGTT and fasting glucose revealing a 5.9% and 3.2% prevalence of diabetes respectively, while prediabetes rates varied significantly among all diagnostic methods and were associated with factors like age and body composition issues.
This article highlights the evaluation strategies of a complex programme, which were essentially based on a pluralist, integrating approach founded on the use of mixed methods. The programme under analysis is the National Reading Plan (NRP), a public policy initiative that aims to increase literacy levels and reading habits among the Portuguese population. It was evaluated throughout its first phase, which lasted five years (2006-2011), using an evaluation model that made it possible to continuously and systematically monitor and analyse the way in which this programme was developed and implemented.
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