Objectives: To investigate the association between selected single nucleotide polymorphisms (SNPs) with cervical insufficiency and its relationship with obstetric history.
Methods: Twenty-eight women with cervical insufficiency (case group) and 29 non-pregnant women (control group) were included. The SNPs sequenced included rs2586490 in collagen type I alpha 1 chain (), rs1882435 in collagen type IV alpha 3 chain (), rs2277698 in metallopeptidase inhibitor 2 (), and rs1800468 in transforming growth factor beta 1 ().