Publications by authors named "Ana Paula Spizzirri"
Background: Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a severe condition mainly affecting children. It is one of the leading causes of acute kidney injury in the pediatric population. There is no established therapy for this disease.
View Article and Find Full Text PDFWe report on a 14-year-old girl who developed post-transplantation smooth muscle tumours (PTSMT) located in the spleen, lungs, liver, and central nervous system (CNS), 4 years after kidney transplantation. She was asymptomatic, and the disease was detected during the work-up for a urinary tract infection. Diagnosis was performed by the analysis of a tissue specimen, through the biopsy of a lung tumour, which revealed a proliferation of spindle-shaped cells which were positive for actin and vimentin.
View Article and Find Full Text PDFArticle Synopsis
- Gram-negative peritonitis (GNP) significantly affects children on long-term peritoneal dialysis, with a study analyzing 379 cases from 308 children across 28 countries showing that 74% responded well to initial treatment.
- Risk factors for treatment failure include severe abdominal pain and bacterial resistance, while monotherapy with cefazolin yielded similar recovery rates as broader-spectrum antibiotics.
- The study advocates for personalized empiric treatment based on susceptibility data and suggests that narrowing antibiotic therapy does not compromise patient outcomes.
Background: We aimed to determine the prevalence of hypoalbuminemia in STEC-HUS patients with hemorrhagic colitis (HC) and whether serum albumin level (SAL), leukocyte count, hematocrit and serum sodium level (SSL) are prognostic markers of HC, central nervous system disease (CNSd) and/or dialysis requirement and evaluate if hypoalbuminemia is associated with fecal protein losses.
Methods: We prospectively evaluated STEC-HUS patients treated at our institution from 9/2011 to 2/2019, analyzing the presence of HC, CNSd and dialysis requirement and SAL, SSL, leukocytes, hematocrit and α1-antitrypsin clearance.
Results: We evaluated 98 patients, with mean age of 33.