Publications by authors named "Ana Paula Silva Azevedo-Santos"
Human papillomavirus infection affects the immune microenvironment and antigen presentation in penile cancer.
Sulayne Janayna Araujo Guimarães André Alvares Marques Vale Mirtes Castelo Branco Rocha Ana Luiza de Araújo Butarelli Jenilson Mota da Silva Ana Paula Silva Azevedo-Santos
Front Oncol
October 2024
Article Synopsis
- Penile squamous cell carcinoma (PSCC), mainly affecting poorer regions, has risk factors such as low socioeconomic status, phimosis, and HPV infection, but its immune response and treatment options are still unclear.
- The study collected data from 30 PSCC patients (mostly HPV-positive) and 19 healthy donors to analyze immune cell behavior and utilize a tumor-mimicking environment created from HPV-positive tumor cultures.
- Results indicated that HPV-positive tumors had fewer T lymphocytes and that dendritic cells in these patients were less mature and had lower activation compared to healthy controls, potentially affecting the immune response and disease progression.
Article Synopsis
- This study investigates the antitumoral properties of a fungal extract sourced from a polluted lagoon in Northeastern Brazil.
- The Ethyl Acetate Extracellular Extract (EAE) was tested on solid Ehrlich tumors in mice, showing significant tumor size reduction across various dosages (4, 20, and 100 mg/kg) while ensuring no harmful side effects.
- The findings reveal that the extract is rich in meroterpenoids, supports immunomodulation, and suggests that fungal fermentation could be an effective method for developing new antitumor therapies.
Could Increased Expression of Hsp27, an "Anti-Inflammatory" Chaperone, Contribute to the Monocyte-Derived Dendritic Cell Bias towards Tolerance Induction in Breast Cancer Patients?
Ana Paula Silva de Azevedo-Santos Mirtes Castelo Branco Rocha Sulayne Janayna Araujo Guimarães André Alvares Marques Vale Fabio Martins Laginha
Mediators Inflamm
June 2020
Dendritic cells (DCs) are the most efficient - and link the innate immune sensing of the environment to the initiation of adaptive immune responses, which may be directed to either acceptance or elimination of the recognized antigen. In cancer patients, though DCs would be expected to present tumor antigens to T lymphocytes and induce tumor-eliminating responses, this is frequently not the case. The complex tumor microenvironment subverts the immune response, blocks some effector mechanisms, and drives others to support tumor growth.
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