Home-based inspiratory muscle training in pediatric patients after kidney transplantation: a randomized clinical trial.

Background: Chronic kidney disease (CKD) represents the irreversible stages of renal failure and is a growing worldwide public health issue associated with increases in morbidity, mortality, and decreased quality of life. Kidney transplantation is considered one of the best treatment options in this population. However, even after surgery, respiratory muscle strength is below normal values, and inspiratory muscle training (IMT) improves respiratory muscle function, strength, and endurance.

[Model of high-fat diet-induced obesity associated to insulin resistance and glucose intolerance].

Objective: Validate a model of high-fat diet-induced obesity, of low cost, easy reproducibility, that could express characteristics observed in human, and would enable subsequent therapy proposals.

Materials And Methods: Sixteen Swiss mice received a standard diet (DP) or high-fat diet (DH) for 10 weeks.

Results: Although the DP group had greater water (p < 0.