Publications by authors named "Ana Paula M Oliveira"
Enalapril maleate (EM) is a widely used anti-hypertensive drug which is unstable when mixed with excipients. Enalaprilate and diketopiperazine (DPK) are the main degradation products of enalapril. The in situ preparation of enalapril sodium salt (NaE) has been used to improve drug stability in dosage forms; however, gas release and product rejection ensue when the chemical reaction for obtaining the sodium salt is not completely finished before packaging.
View Article and Find Full Text PDFBackground: The rat lungworm Angiostrongylus cantonensis can cause eosinophilic meningoencephalitis in humans. This nematode's main definitive hosts are rodents and its intermediate hosts are snails. This parasite was first described in China and currently is dispersed across several Pacific islands, Asia, Australia, Africa, some Caribbean islands and most recently in the Americas.
View Article and Find Full Text PDFArticle Synopsis
- The rat lungworm Angiostrongylus cantonensis has been isolated for the first time from the giant African snail Achatina fulica in two Brazilian states, indicating its widespread presence in the country.
- The identification was based on comparing the morphology of the isolated worms with known samples from other regions, revealing only minor variations among species.
- This discovery highlights the importance of studying the transmission dynamics of this nematode through mollusks and rodents in Brazil, especially in port areas where these species may interact.