1α,25(OH)D-glycosides from leaves extract induce myoblasts differentiation through p38 MAPK and AKT activation.

We have previously shown that leaf extract (SGE) increases VDR protein levels and promotes myoblast differentiation. Here, we investigated whether p38 MAPK and AKT are involved in SGE actions. Cell-cycle studies showed that SGE prompted a peak of S-phase followed by an arrest in the G0/G1-phase through p38 MAPK.