Preconditioning by Moderate-Intensity Exercise Prevents Gentamicin-Induced Acute Kidney Injury.

A strict correlation among proximal tubule epithelial cell dysfunction, proteinuria, and modulation of the Renin-Angiotensin System and Kalikrein-Kinin System are crucial factors in the pathogenesis of Acute Kidney Injury (AKI). In this study, we investigated the potential protective effect of preconditioning by moderate-intensity aerobic exercise on gentamicin-induced AKI. Male Wistar rats were submitted to a moderate-intensity treadmill exercise protocol for 8 weeks, and then injected with 80 mg/kg/day s.

Double blind carbohydrate ingestion does not improve exercise duration in warm humid conditions.

The positive effects of carbohydrate (CHO) supplementation on endurance exercise are well documented but the placebo (PLA(c)) effect can make the ergogenic qualities of substances more difficult to determine. Therefore, this study tested the effect of double blind ingestion of PLA(c) and CHO(c) in capsules versus known capsule (CHO(k)) ingestion on prolonged exercise heat stress. Nine well trained male volunteers (mean+/-S.