Environmentally sustainable: How are the practices in the organic food tourist route?

This study analyzes Environmentally Sustainable Practices (ESPs) in the Organic Food Tourist Route (OFTR) in South Brazil. Data collection included interviews with open and closed questions about ESPs and the Barometer of Tourism Sustainability (BTS) tool. Eight owners or managers of OFTR's enterprises answered questions online or personally.

Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer.

Despite major improvements in the management of advanced prostate cancer over the last 20 years, the disease remains invariably fatal, and new effective therapies are required. The development of novel hormonal agents and taxane chemotherapy has improved outcomes, although primary and acquired resistance remains problematic. Inducing cancer cell death via apoptosis has long been an attractive goal in the treatment of cancer.

EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas.

As we age, our tissues are repeatedly challenged by mutational insult, yet cancer occurrence is a relatively rare event. Cells carrying cancer-causing genetic mutations compete with normal neighbors for space and survival in tissues. However, the mechanisms underlying mutant-normal competition in adult tissues and the relevance of this process to cancer remain incompletely understood.

Orofacial trauma and mouthguard use in Brazilian rugby union players.

Background/aim: Rugby union represents a high-risk sport for orofacial trauma due to its impact collisions and repetitive tackles. The aim of this study was to investigate the prevalence of orofacial trauma according to mouthguard use among a sample of Brazilian rugby union players.

Methods: An online questionnaire was sent to the 16 best rugby union clubs in Brazil.

Determinants for traumatic orofacial injuries in sport: Extrinsic factors in a scoping review.

Background/aim: Sports practices carry a risk for orofacial injuries and, to avoid them, preventive measures are necessary. The aim of this study was to investigate a web of extrinsic determinants for orofacial trauma in sports.

Materials And Methods: Through a scoping review, eight extrinsic risk factors for sports-related orofacial trauma emerged from the thematic analysis.

Prevalence of dentofacial injuries among combat sports practitioners: A systematic review and meta-analysis.

Background/aim: Combat sports might result in injuries to the face and teeth. However, it is unclear how often they occur and which sports presents the highest rates. The aim of this study was to investigate the prevalence of dentofacial injuries in combat sports participants.

Sustained effect of bone marrow mononuclear cell therapy in axonal regeneration in a model of optic nerve crush.

In adult mammals, the regeneration of the optic nerve is very limited and at the moment there are several groups trying different approaches to increase retinal ganglion cell (RGC) survival and axonal outgrowth. One promising approach is cell therapy. In previous work, we performed intravitreal transplantation of bone-marrow mononuclear cells (BMMCs) after optic nerve crush in adult rats and we demonstrated an increase in RGC survival and axon outgrowth 14 days after injury.

Effect of radiotherapy on the radiopacity and flexural strength of a composite resin.

The aim of this study was to evaluate the effect of radiotherapy on the radiopacity and flexural strength of composite resin. Forty Z250 composite resin specimens were polymerized using a halogen light-curing unit and divided into 5 groups, in accordance with the radiotherapy dose: G1- without irradiation, G2- 30 Gy, G3- 40 Gy, G4- 50 Gy and GS- 60 Gy Digital images were obtained using a GE 100 X-ray. Radiopacity values were obtained with the Digora digital imaging system and the flexural strength was evaluated with an EMIC universal testing machine.