Publications by authors named "Ana P Ferraz"
Article Synopsis
- This study explores how hypothyroidism affects the development of pulmonary arterial hypertension (PAH) in male Wistar rats using a monocrotaline to induce PAH and methimazole to induce hypothyroidism.
- Results showed that hypothyroid rats (MMZ + MCT group) had improved heart function and reduced right ventricular pressure compared to PAH rats (MCT group), while both groups had lower thyroid hormone levels.
- The conclusion indicates that hypothyroidism may help mitigate mitochondrial dysfunction and slow down the progression of PAH caused by monocrotaline.
Purpose: In the present study, the therapeutic efficacy of a selective BK channel opener (compound X) in the treatment of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) was investigated.
Methods: PAH was induced in male Wistar rats by a single injection of MCT. After two weeks, the MCT-treated group was divided into two groups that were either treated with compound X or vehicle.
Aim: The present study investigated the effects of anabolic steroid (AS) excess on blood pressure regulation.
Methods: Male Wistar rats were treated with nandrolone decanoate (AS) or vehicle (CTL) for 8 or 10 weeks. Saline (1.