Publications by authors named "Ana P Batista Mesquita Sauvage"
Thromb Haemost
October 2023
Article Synopsis
- Emicizumab is a bispecific antibody used to treat hemophilia A, but typical coagulation tests can't accurately measure its effects due to over-correction.
- This study involved six adult patients receiving emicizumab, where their treatment response was monitored through thrombin generation (TG) and fibrin clot formation (FCF) over several weeks.
- Results indicated that TG and FCF improved significantly with treatment, suggesting that these global coagulation assays could serve as valuable indicators of emicizumab's effectiveness and contribute to more personalized treatment plans.
Int J Mol Sci
December 2020
Article Synopsis
- Glanzmann thrombasthenia (GT) patients have defective levels of a protein called GP IIb/IIIa, leading to difficulties in platelet aggregation.
- A study examined the procoagulant abilities of GT patients' platelets using flow cytometry and found they generated more procoagulant COAT platelets compared to healthy individuals.
- GT patients also showed higher cytosolic calcium levels during activation, suggesting a potential link between GP IIb/IIIa signaling and increased procoagulant activity.
Thromb Haemost
February 2021
Article Synopsis
- FXI deficiency leads to unpredictable bleeding, and the study investigates how analyzing both tissue factor (TF)-dependent and -independent coagulation phases can improve diagnostics.
- The research examined plasma samples from healthy individuals, FXI-deficient patients with varying bleeding phenotypes, and those who received FXI replacement to understand hemostasis.
- Findings indicate that specific TF-independent coagulation parameters can effectively differentiate between FXI-deficient bleeders and non-bleeders, highlighting their potential for better clinical assessment and treatment management.
