Publications by authors named "Ana Ortiz-Vallecillo"
Article Synopsis
- Capacitation in sperm involves tyrosine phosphorylation (TP), a key marker, but lifestyle factors like obesity and smoking affect semen quality without a clear understanding of their mechanisms on TP.
- A study analyzed TP levels in sperm from 40 donors and found that being overweight or smoking did not significantly change the percentage of sperm showing TP, but did relate to higher basal TP levels and increases after incubation.
- Additionally, while cryopreservation slightly raised TP levels after capacitation, most thawed samples showed increased TP levels, indicating that lifestyle and cryopreservation impact TP dynamics during sperm capacitation.
Article Synopsis
- The main goal of a PGT-HLA matching program is to have a healthy baby that can help treat or cure an older sibling who is sick.
- Some people have successfully had healthy babies that match, but there have been many attempts that didn't work.
- The authors studied different ways to improve these programs and shared a success story after a previous failure using their suggested approaches.
Clinical outcome in assisted reproduction techniques (ARTs) is mainly influenced by the quality of gametes used. It is known that a high percentage of sperm DNA fragmentation (DNAf) decreases the success of ART clinical results. Therefore, techniques such as magnetic-activated cell sorting (MACS) help to improve results in cases of patients with a high percentage of DNAf.
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