Publications by authors named "Ana Olsavszky"
Article Synopsis
- Language barriers in healthcare can lead to serious issues like misdiagnosis and high medical errors, highlighting the need for effective translation methods that go beyond traditional interpreters.
- * This pilot study evaluates Translatly, a digital translation platform, to see how well it can help healthcare professionals communicate during consultations, particularly assessing its usability and acceptance in clinical settings.
- * The study involved interviews and observations in a German hospital, focusing on how the platform functions with volunteer translators, primarily medical students, offering support in multiple languages.
Background: This study analyzed the role of Stabilin-1 on hepatic melanoma metastasis in preclinical mouse models.
Methods: In mice (Stab1 KO), liver colonization of B16F10 and Wt31 melanoma was investigated. The numbers, morphology, and vascularization of hepatic metastases and the hepatic microenvironment were analyzed by immunofluorescence.
Background: Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10-20% of stage 4 patients, came to the fore of melanoma research, as it recently evolved as decisive indicator of treatment resistance to immune checkpoint inhibition.
Methods: Hepatic metastases were induced by intrasplenic injection of five different murine melanoma cell lines.
The Class H scavenger receptors Stabilin-1 (Stab1) and Stabilin-2 (Stab2) are two of the most highly expressed genes in liver sinusoidal endothelial cells (LSECs). While Stab1-deficient (Stab1KO) and Stab2-deficient (Stab2KO) mice are phenotypically unremarkable, Stab1/2-double-deficient (StabDKO) mice exhibit perisinusoidal liver fibrosis, glomerulofibrotic nephropathy and a reduced life expectancy. These conditions are caused by insufficiently scavenged circulating noxious blood factors.
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