Topical use of hyperoxygenated fatty acids decreases surgical site infection in patients following laparoscopic cholecystectomy. A randomized controlled trial.

Background: To date, the topically effect of hyperoxygenated fatty acids (HOFA) on the control of surgical site infection (SSI) is still unclear.

Objective: To assess the effect of topical application of a HOFA solution on the umbilical trocar site after laparoscopic cholecystectomy on SSI. The occurrence of trocar site incisional hernia (TSIH) was also analyzed.

NUTRI-ONCOCARE: New integral nutrition care model to prevent and treat malnutrition in cancer patients.

Objective: The maximum expression of malnutrition in cancer patients is  cancerous cachexia, always linked to an unfavorable prognosis. Given its  evolutionary nature it is recommended to detect and act early in those patients with nutritional risk. The objective is to propose an action  algorithm for the nutritional approach of patients with solid tumors.

Adequacy of Parenteral Nutrition in Preterm Infants According to Current Recommendations: A Study in A Spanish Hospital.

Background: In preterm infants, it is important to ensure adequate nutritional intake to accomplish foetal growth requirements. This study evaluated clinical practice regarding the prescription of parenteral nutrition in preterm infants in the neonatology unit of a tertiary hospital.

Methods: It was a retrospective observational study of a sample of preterm infants (n = 155) born between January 2015 and December 2017 who were prescribed parenteral nutrition.

Stability and compatibility of ondansetron with haloperidol in parenteral admixtures.

Background: The chemical stability of coadministered ondansetron (OND) and haloperidol (HAL) in parenteral admixtures has not been described yet.

Objective: The aim of the present work is to study the chemical stability and the compatibility of OND and HAL admixtures.

Methods: Normal saline solution and dextrose were used to prepare the admixture solutions of the drugs; the materials of the containers were the original plastic bags of the diluents and the stability was studied at 20°C.

Pharmacokinetic monitoring of chronic treatment with digoxin from Primary Health Care.

Introduction: The serum digoxin concentration (SDC) should be between 0.8 and 2 ng/ml. The objective is to assess the pharmacokinetic monitoring of SDC performed from primary healthcare (PH) in patients with chronic treatment.

[Subcutaneous drug administration in palliative care].

Objective: Develop a guide that compiles all the information available in the literature for healthcare staff on the administration of drugs subcutaneously in palliative care patients of the Hospital Unit of home.

Method: It is designed a summary table of drugs likely to be administered subcutaneously in palliative care patients through the revision of the technical reports of the manufacturers and other literature published by scientific organizations, in addition to the literature search on Pubmed® and Micromedex®.

Results: We have reviewed 65 drugs and a guide has been developed of recommendations depending on whether there is information of his administration by subcutaneous or, if on the contrary, its use is contraindicated.

Acute seizures due to a probable interaction between valproic acid and meropenem.

Objective: To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures.

Case Summary: A 21-year-old woman presented to our emergency department because of a new-onset, generalized tonic-clonic seizure and was admitted to the intensive care unit. Treatment with valproic acid 1000 mg as a continuous intravenous infusion over 24 hours was initiated.