Publications by authors named "Ana Mordoh"
Background: Cutaneous melanoma is the skin cancer with the highest mutational burden and metastatic rate. Early genetic alterations and biomarkers of distant progression are a point of interest. In addition to germline-susceptibility loci, almost 30% of melanomas arise from precursor benign nevi lesions, providing a source for malignant transformation.
View Article and Find Full Text PDFThe CSF-470 vaccine (VACCIMEL) plus BCG and GM-CSF as adjuvants has been assayed in cutaneous melanoma patients. In the adjuvant randomized Phase II study CASVAC-0401, vaccinated patients had longer distant metastasis-free survival (DMFS) than those treated with IFNα2b. Five years after locking the data, an actualization was performed.
View Article and Find Full Text PDFArticle Synopsis
- Direct immunofluorescence (DIF) is a key method for diagnosing bullous diseases and autoimmune conditions, but its detection rate can be influenced by factors like the biopsy site, the number of biopsies, and the instruments used.
- A study at the Universidad de Buenos Aires reviewed 136 cases and found that DIF detection rates varied among conditions, with the highest rate in pemphigus vulgaris (100%) and a lower rate in bullous pemphigoid (55.6%).
- It was discovered that increasing the number of biopsies improved detection rates, and biopsies taken with a punch had a significantly higher detection rate compared to scalpel biopsies (71.7% vs. 39.1%).