Publications by authors named "Ana Miric"
Article Synopsis
- A series of novel tryptamine-derived Schiff bases was synthesized to explore new pharmacological properties, leveraging the indole pharmacophore.
- TSB4 exhibited superior antifungal activity compared to the standard drug Fluconazole, while TSB6 demonstrated cytotoxic effects on HCT-116 cancer cells with selectivity for healthy fibroblast cells.
- Additional analysis showed strong binding to CT-DNA and favorable ADME properties, indicating potential for oral bioavailability and drug-like characteristics.
Article Synopsis
- Pharmacological agents with antioxidant properties play a crucial role in preventing and treating health issues linked to oxidative stress, such as cancer.
- A study assessed 14 new compounds called N-pyrocatechoyl and N-pyrogalloyl hydrazones (N-PYRs), revealing their strong ability to neutralize harmful free radicals and their beneficial antioxidant pathways.
- Further analysis showed that four of these compounds selectively targeted cancer cells while also demonstrating antibacterial effects, indicating their potential as effective antioxidant agents with dual therapeutic applications.
Objective: This study aimed to evaluate the dental pulp responses to recombinant human erythropoietin (rhEPO) and/or mineral trioxide aggregate (MTA) in pulp capping of inflamed dental pulp in vivo.
Materials And Methods: In accordance with ARRIVE guidelines, pulp inflammation was induced by exposing the maxillary first molars (n = 64) of Wistar rats (n = 32) to the oral environment for two days. The exposed pulps were randomly assigned four groups based on the pulp capping material: rhEPO, MTA, MTA + rhEPO, or an inert membrane.
Nowadays, biomedicine is a multidisciplinary science that requires a very broad approach to the study and analysis of various phenomena essential for a better understanding of human health. This study deals with the use of numerical simulations to better understand the processes of cancer viability and apoptosis in treatment with commercial chemotherapeutics. Starting from many experiments examining cell viability in real-time, determining the type of cell death and genetic factors that control these processes, a lot of numerical results were obtained.
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