Publications by authors named "Ana Medel-Martinez"
Introduction: Suspected preterm labour (SPL) is an obstetric complication that occurs in 9% of all pregnancies and is the leading cause of antenatal hospital admissions. More than half of women with SPL deliver a premature baby which is a known risk factor for developing cardiovascular and metabolic disorders in childhood and later in adult life. On the other hand, the other half of these women will deliver at term, labelled as 'false preterm labour'.
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- Post-coronavirus disease condition (PCC) continues to impact many people, but there's a lack of reliable diagnostic biomarkers to differentiate it from recovery after acute COVID-19.
- A study compared biomarkers between two groups: people with PCC and those who recovered from COVID-19 within three months, both consisting of 85 individuals.
- The results showed PCC individuals had significant changes in 49 out of 167 markers, and a specific panel of four biomarkers could distinguish PCC from recovery with over 88% accuracy.
Exosomes are cell-derived extracellular vesicles (EVs) with diameters between 30 and 120 nm. In recent years, several studies have evaluated the therapeutic potential of exosomes derived from different fluids due to their low immunogenicity and high biocompatibility. However, producing exosomes on a large scale is still challenging.
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- * Out of 104 placentas examined, SARS-CoV-2 was found only in samples from the Pre-VOC group, with no detections in the VOC group, indicating a significant decrease in placental infection rates with the emergence of VOCs.
- * Furthermore, complications like preterm birth and hypertensive disorders were more common in the Pre-VOC group, while vaccination status did not show a notable impact on outcomes among women with VOC infections.
Due to their ease of isolation and their properties, mesenchymal stem cells (MSCs) have been widely investigated. MSCs have been proved capable of migration towards areas of inflammation, including tumors. Therefore, they have been suggested as vectors to carry therapies, specifically to neoplasias.
View Article and Find Full Text PDFIntroduction: Studies described an increased frequency of hypertensive disorders of pregnancy (HDP) after a COVID-19 episode. There is limited evidence about SARS-CoV-2 viral load in placenta. This study aimed to investigate the relationship between SARS-CoV-2 viral load in the placenta and clinical development of HDP after COVID-19 throughout different periods of gestation.
View Article and Find Full Text PDFExosomes are microvesicles of nanometric size involved in the communication between cells and tissues. Inside their bilipidic membrane they carry nucleic acids such as cargos (DNA, miRNA, ). Some of the advantages that make exosomes very attractive therapeutic vehicles are (i) their tropism through different tissues, (ii) the ability to pass biological barriers and (iii) the protection of the encapsulated material from the immune system and degradation.
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