Peri-operative chemotherapy for resectable colorectal liver metastasis: does timing of systemic therapy matter?

Background: The benefit of pre-operative chemotherapy in patients with resectable colorectal liver metastases (CRLM) remains ill defined. We sought to evaluate the impact of peri-operative systemic chemotherapy timing on outcome following resection of CRLM.

Methods: 676 patients who underwent surgery for CRLM were identified from two hepatobiliary center databases.