Publications by authors named "Ana Marina B de Figueiredo"
J Fungi (Basel)
March 2023
Article Synopsis
- Paracoccidioidomycosis (PCM) is a fungal infection influenced by the body’s immune response, with different clinical forms tied to these responses.
- A study identified specific genetic variants, notably rs11053595 in the Dectin-1 receptor gene and rs62290169 in the CD133 gene, that affect cytokine production in response to the fungus.
- Blocking the Dectin-1 receptor eliminated IL-1β production, while a particular genotype (rs62290169-GG) was linked to a higher presence of Th1 cells, indicating these genes play a significant role in determining the immune response and disease outcome in PCM.
