Publications by authors named "Ana Maria Guzman Prieto"
Int J Antimicrob Agents
November 2015
Article Synopsis
- Enterococcus faecium is becoming a significant hospital-acquired infection that shows increased resistance to the antibiotic tigecycline following therapy.
- Whole-genome sequencing of clinical isolates revealed that sensitive strains exhibited mutations in the rpsJ gene, which is linked to the ribosomal subunit involved in tigecycline binding.
- The study found multiple mutations and nucleotide deletions in resistant strains, indicating that changes in the rpsJ gene are crucial for reduced tigecycline susceptibility and potential resistance mechanisms in Enterococcus faecium.
