Pancreatic fibrosis in rats and its response to antioxidant treatment.

Context: Oxidative stress plays a role in the development of pancreatic fibrosis.

Objectives: In the present study, we hypothesized that the administration of an antioxidant complex could ameliorate cerulein and cyclosporin A pancreatic fibrosis, assessed by changes in oxidative stress and a histopathological study in an experimental rat model.

Animals: Four groups of ten rats each.