CD105 microvessels density, VEGF, EGFR-1 and c-erbB-2 and their prognostic correlation in different subtypes of cervical adenocarcinoma.

In this study, we have investigated the immunohistochemical expression of endoglin (CD105), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR-1) and epidermal growth factor receptor 2 (c-erbB-2) and their prognostic correlation in 13 cases of cervical adenocarcinomas with mucinous, endometrioid and serous type differentiation. Our study revealed that for uterine cervix adenocarcinoma the most intense angiogenic activity occurs at the invasion front of these tumors. In addition, we noticed a trend towards increased CD105 MVD values in those cases in which were recorded the highest VEGF and c-erbB-2 reactivity.