EGF-liposomes promote efficient EGFR targeting in xenograft colocarcinoma model.

Aim: Development of EGF-liposomes (LP-EGF) for selective molecules delivery in tumors expressing EGFR.

Material & Methods: In vitro cellular interaction of EGF-LP and nontargeted liposomes (LP-N) was assayed at 37 and 4 °C in cells expressing different EGFR levels. Receptor-mediated uptake was investigated by competition with a monoclonal antibody anti-EGFR.