Patterned cell adhesion associated with tissue deformations during dorsal closure in Drosophila.

Cell shape changes within epithelia require the regulation of adhesive molecules that maintain tissue integrity. How remodelling of cell contacts is achieved while tissue integrity is maintained remains a fundamental question in morphogenesis. Dorsal Closure is a good system to study the dynamics of DE-Cadherin during morphogenesis.

Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila.

During development tissue deformations are essential for the generation of organs and to provide the final form of an organism. These deformations rely on the coordination of individual cell behaviours which have their origin in the modulation of subcellular activities. Here we explore the role endocytosis and recycling on tissue deformations that occur during dorsal closure of the Drosophila embryo.