Publications by authors named "Ana Marenco-Flores"
Article Synopsis
- Acute liver failure (ALF) rapidly damages the liver and can lead to multi-organ failure, with liver transplantation (LT) significantly improving survival rates in the U.S.
- This study analyzed data from UNOS between 2002-2020 to examine long-term survival for ALF patients and identify risk factors affecting both waitlist and post-transplant outcomes.
- Key findings reveal that acetaminophen (APAP) overdose and unknown causes increase waitlist removal risks, while Wilson disease (WD) is linked to better survival rates post-transplant; however, patients with autoimmune hepatitis (AIH) and APAP have poorer survival outcomes.
Background And Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD), in the context of autoimmune hepatitis (AIH) among liver transplantation (LT) candidates or recipients remains poorly understood. This study compares waitlist and post-LT outcomes in patients with MASLD/AIH to MASLD and AIH alone.
Methods: Using the united network organ sharing database (2002-2022), we compared waitlist outcomes and post-LT survival among patients with MASLD/AIH (n = 282), AIH (n = 5812), and MASLD (n = 33 331).
The cornerstone treatment for primary biliary cholangitis (PBC) is ursodeoxycholic acid (UDCA), but many patients exhibit an incomplete response, leading to disease progression. Risk prediction models like the GLOBE and UK-PBC scores hold promise for patient stratification and management. We aimed to independently assess the predictive accuracy of these risk scores for UDCA response in a prospective U.
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- Autoimmune liver diseases (AILDs) like autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis show varied survival rates post-liver transplant (LT), influenced by factors such as disease severity and socio-economic conditions.
- Analyzing data from 13,702 AILD patients listed for LT from 2002 to 2021, the study focused on waitlist removal, patient survival, and graft survival, taking into account demographics, health conditions, and social factors.
- Findings revealed that lack of college education and public insurance increased waitlist removal and negatively affected both patient and graft survival, while unemployment had the most significant adverse effect on survival outcomes; U.S. citizenship status did not impact
Primary biliary cholangitis (PBC) prompts liver transplantation (LT) due to cholestasis, cirrhosis, and liver failure. Despite lower MELD scores, recent studies highlight higher PBC waitlist mortality, intensifying the need for alternative transplantation strategies. Living donor liver transplant (LDLT) has emerged as a solution to the organ shortage.
View Article and Find Full Text PDFIn this study we aimed to evaluate and compare the overall performance of the Khorana, PROTECHT, and CONKO scores as predictive scores for the occurrence of venous thromboembolism (VTE) among ambulatory Hispanic patients with solid tumors. We included all outpatients with newly diagnosed solid tumors receiving systemic chemotherapy in Hospital San Juan Dios, San José, Costa Rica, from January to December 2021. For each patient the Khorana, PROTECHT, and CONKO scores were calculated at the beginning of treatment.
View Article and Find Full Text PDFBackground: The Khorana risk score (KRS) for prognosis of venous thromboembolism (VTE) has been rarely explored in Hispanic populations.
Objective: To determine the value of the KRS for prediction of VTE and overall survival (OS) among Hispanic individuals with cancer.
Methods: We retrospectively evaluated all outpatients with newly diagnosed solid tumours receiving systemic chemotherapy in Hospital San Juan Dios, San José, Costa Rica, from January to December 2021.