Publications by authors named "Ana M Rodriguez-Salgado"
Background: Little is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America.
Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and PD with frailty in a large multi-country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population.
Article Synopsis
- * Results indicate that individuals with over 70% Native American or African American ancestry tend to have worse SDoH indicators, like lower education and socioeconomic status.
- * Importantly, after accounting for SDoH factors, genetic ancestry did not significantly influence dementia risk or cognitive performance, highlighting the greater importance of social and environmental factors in these communities.
Background: Parkinson's disease (PD) is a rapidly growing neurodegenerative disorder, but up-to-date epidemiological data are lacking in Latin America. We sought to estimate the prevalence and incidence of PD and parkinsonism in Latin America.
Methods: We searched Medline, Embase, Scopus, Web of Science, Scientific Electronic Library Online, and Literatura Latino-Americana e do Caribe em Ciências da Saúde or the Latin American and Caribbean Health Science Literature databases for epidemiological studies reporting the prevalence or incidence of PD or parkinsonism in Latin America from their inception to 2022.
Background: Little is known about the burden of parkinsonism and Parkinson's disease (PD) in Latin America. Better understanding of health service use and clinical outcomes in PD is needed to improve its prognosis.
Objective: The aim of the study was to estimate the burden of parkinsonism and PD in six Latin American countries.
Background: Neuropsychiatric symptoms (NPSs) are common in neurodegenerative diseases; however, little is known about the prevalence of NPSs in Hispanic populations.
Methods: Using data from community-dwelling participants age 65 years and older enrolled in the 10/66 study (N = 11,768), we aimed to estimate the prevalence of NPSs in Hispanic populations with dementia, parkinsonism, and parkinsonism-dementia (PDD) relative to healthy aging. The Neuropsychiatric Inventory Questionnaire (NPI-Q) was used to assess NPSs.
Article Synopsis
- Alzheimer's disease and related dementia (ADRD) significantly affect low-middle-income countries (LMICs), but these regions are underrepresented in clinical trials for treatment.
- A study analyzed the distribution of ADRD clinical trials globally and found that only 11.6% of trials for disease-modifying therapies occurred in emerging economies, with only 2.0% in low-middle-income nations.
- Key barriers to conducting trials in LMICs include financial limitations, insufficient industry support, regulatory challenges, and operational issues, highlighting a significant health equity gap that needs to be addressed.
Race, Genetic Admixture, and Cognitive Performance in the Cuban Population.
J Gerontol A Biol Sci Med Sci
February 2022
Background: Population aging will lead to a dramatic increase in dementia prevalence, which will disproportionally affect racial minorities. The presence of racial differences in dementia prevalence has been widely reported in United States, but there are no relevant studies on this topic in low- and middle-income countries.
Methods: In a cross-sectional survey, 2944 older Cubans were recruited at a community-based level aimed to identify the effects of self-identified race and genetic admixture on cognitive performance.
Background: Rapid technological advances offer a possibility to develop cost-effective digital cognitive assessment tools. However, it is unclear whether these measures are suitable for application in populations from Low and middle-income countries (LMIC).
Objective: To examine the accuracy and validity of the Brain Health Assessment (BHA) in detecting cognitive impairment in a Cuban population.