Publications by authors named "Ana M Matas-Cobos"
Article Synopsis
- Inflammation is crucial in the development of acute pancreatitis (AP), and genetic variations may influence its severity.
- A study of 269 patients found that the rs11209026 A allele is linked to the presence of AP, and its interaction with rs1800629 significantly raises susceptibility.
- The rs42490-G allele was associated with a higher risk of severe pancreatitis and increased mortality, suggesting genetic factors play a role in AP severity and outcomes.
Red blood cell transfusion after a global strategy for early detection and treatment of iron deficiency anemia: three-year results of a prospective observational study.
Transfusion
June 2018
Background: Anemia is the main indication for red blood cell (RBC) transfusion and iron deficiency is the most prevalent, preventable, and treatable cause of anemia worldwide. We aimed to assess the impact of iron deficiency anemia (IDA) on RBC transfusion by means of a program for prevention, early detection, and treatment.
Study Design And Methods: A prospective observational study was conducted starting in 2014 after an intervention in clinical practice in Melilla, a peripheral city isolated by 207 km sea distance to nearest continental Spain.
Objectives: Acute pancreatitis (AP) is severe in up to 20% of patients, with a high mortality rate. Quantification of serum TH1 and TH2 cytokines may provide objective evidence to assess the severity of AP and predict its course.
Methods: One hundred seventeen patients were studied, measuring serum concentrations of interleukin (IL)1β, IL2, IL4, IL5, IL6, IL10, IL12p70, IL13, IL18, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN) γ, and tumor necrosis factor (TNF) α.
Background And Aim: The study aims to assess and compare the predicting ability of some scores and biomarkers in acute pancreatitis.
Methods: We prospectively collected data from 269 patients diagnosed of acute pancreatitis, admitted to Virgen de las Nieves University Hospital between June 2010 and June 2012. Blood urea nitrogen (BUN), C-reactive protein, and creatinine were measured on admission and after 48 h, lactate and bedside index for severity acute pancreatitis (BISAP) only on admission and RANSON within the first 48 h.
Objectives: Toll-like receptors (TLRs) are damage-associated molecular patterns receptors, which are essential in the activation of the inflammasome cascade, required for the initiation of inflammation. We hypothesized that changes in the function of these receptors caused by genetic polymorphisms in their encoding genes could determine acute pancreatitis (AP) incidence or severity.
Methods: Two hundred sixty-nine patients and 269 controls were included.