Negative correlation between bone mineral density and TSH receptor antibodies in long-term euthyroid postmenopausal women with treated Graves' disease.

Background: Thyrotoxicosis is a cause of secondary osteoporosis. High concentrations of triiodotironine (T3) in Graves' disease stimulate bone turnover, but it is unclear if euthyroidism will always normalize bone metabolism. Thyrotropin (TSH) is known to affect directly the bone metabolism through the TSH receptor and TSH receptor antibodies (TRAb) may have an important role in bone turn-over.

[Multiple FISH and multiple BAND: Application of cytogenetic and molecular techniques in 5 cases].

The techniques of multiple FISH (M-FISH) or fluorescence in situ hybridization with different color assignment for all and each of the human chromosomes, and multiple BAND (M-BAND) or hybridization with different color assignment for each chromosomal band, allow the identification of some alterations that would not be possible to distinguish with classical banding techniques, like the origin of the chromosomal material that constitutes a (non identifiable) marker chromosome or confirming the constitution of the multiple and simultaneous aberrations that occur in cancer cells. We communicate five complex cytogenetic cases that benefited by the employment of this diagnostic strategy, allowing to corroborate or reformulate a previous given conclusion.

Antioxidant vitamins C and E affect the superoxide-mediated induction of the soxRS regulon of Escherichia coli.

The mechanism of activation of Escherichia coli redox sensory protein SoxR is still unclear: a [2Fe-2S] cluster contained in a SoxR dimer is potentially redox-sensitive, but the nature of the signal is unknown. Antioxidant vitamins C (ascorbate) and E (alpha-tocopherol) were used to explore the mechanism of activation of the SoxR protein in vivo. Treating E.