Publications by authors named "Ana M Blazquez de Castro"
Daptomycin is one of the last therapeutic resources for multidrug-resistant gram-positive bacteria. Despite its structural similarities with glycopeptides, its mechanisms of action and resistance are different and in some respects are not completely understood. Mutations in several genes have been associated with daptomycin resistance, especially in , , and , but their role and importance remain to be elucidated.
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- The urine culture remains essential for diagnosing urinary tract infections (UTIs), but many tests yield negative results, suggesting a need for better screening methods to reduce workload and hasten negative result reporting.
- The study tested the UF-1000i flow cytometer for screening urine samples, comparing results between two groups based on bacterial growth levels, showing high sensitivity and reasonable specificity in identifying negative cases for both groups.
- Results indicate that while the UF-1000i could reduce the number of cultures needed—46% reduction for Group 1 and 57.5% for Group 2—the prevalence of false negatives raises concerns about its reliability, depending on patient characteristics and how positive cultures are classified.
Hepatitis B reactivation in a hepatitis B surface antigen-negative patient after allogeneic bone marrow transplant: successful treatment with lamivudine and seroconversion.
Diagn Microbiol Infect Dis
May 2009
Hepatitis B reactivation in hepatitis B surface antigen (HBsAg)-negative and anti-HBsAg antibodies-positive patients is an infrequent complication of chemotherapy, usually with fatal evolution. Here we report an HBsAg-negative patient with a myelodysplastic syndrome, who developed hepatitis B reactivation after chemotherapy and evolved favorably after lamivudine treatment, allowing seroconversion.
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