Publications by authors named "Ana Lupe Motta Studzinski"
Article Synopsis
- The GH/IGF-I somatotropic axis is crucial for growth and has roles in learning and memory through the modulation of glutamate receptors in the brain.
- This study focused on transgenic zebrafish to explore these effects, conducting tests to measure long-term memory (LTM) and analyze brain gene expression.
- Results indicated that transgenic zebrafish exhibited enhanced LTM, increased expression of AMPA and NMDA receptor genes, and a significant rise in igf-I expression, suggesting a strong link between the somatotropic axis and cognitive function in this model.
Homozygote individuals (HO) of the GH-transgenic zebrafish lineage (F0104), despite expressing double the amount of growth hormone (GH) in relation to the hemizygote (HE) individuals, presented smaller growth in relation to the last, and similar to the non-transgenic (NT) group. Through the analysis of the expression of genes of the somatotrophic axis in the livers of HO and NT individuals, it was verified that GHR, JAK2 and STAT5.1 did not present significant differences among the analyzed genotypes (NT and HO).
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