Publications by authors named "Ana Luisa P Ayub"
Article Synopsis
- The study investigates the epigenetic changes in melanoma progression using a four-stage cell line model, examining how CpG methylation varies across different stages: from non-tumorigenic melanocytes to metastatic melanoma cells.
- Researchers identified specific gene promoters that are hypo- and hypermethylated, which characterize distinct malignancy and metastasis signatures, totaling 540 hypo- and 37 hypermethylated promoters for malignancy, and 646 hypo- and 520 hypermethylated promoters for metastasis.
- The findings suggest that specific CpGs could serve as potential markers for predicting poor survival in melanoma patients, as they showed a correlation between DNA methylation and transcriptional levels in key genes linked to melanoma prognosis.
The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous group of neurodevelopmental diseases representing a severe burden to affected individuals and their caretakers. Despite substantial improvement towards understanding of ASD etiology and pathogenesis, as well as increased social awareness and more intensive research, no effective drugs have been successfully developed to resolve the main and most cumbersome ASD symptoms. Hence, finding better treatments, which may act as "disease-modifying" agents, and novel biomarkers for earlier ASD diagnosis and disease stage determination are needed.
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