Publications by authors named "Ana Lucia Estevam Santos"
Dioclea violacea lectin has potent in vitro leishmanicidal activity against Leishmania infantum via carbohydrate recognition domain.
Flávia Eduarda Vidal Barbosa Dimas Batista de Lima Ana Lúcia Estevam Dos Santos Valéria Carlos de Sousa Rita de Cássia Viana Carvalho
Int J Biol Macromol
September 2024
Article Synopsis
- Existing leishmaniasis treatments have limitations and side effects, prompting the exploration of new alternatives like the lectin DVL from Dioclea violacea seeds.
- DVL showed significant leishmanicidal effects against Leishmania infantum in vitro, inducing reactive oxygen species and damaging the parasite's membrane, with an effective concentration of 49.37 μg/mL.
- DVL enhanced the effectiveness of traditional drugs like amphotericin B and glucantime, reduced macrophage infection rates, and exhibited no toxicity in healthy cells, indicating its potential as a treatment for visceral leishmaniasis.
Is the orofacial antinociceptive effect of lectins intrinsically related to their specificity to monosaccharides?
Gerlânia de Oliveira Leite Sacha Aubrey Alves Rodrigues Santos Francisca Magnólia Diógenes Holanda Bezerra Francisco Evilyn Sena E Silva Antonia Deyse de Castro Ribeiro Romério Rodrigues Santos Silva Maria Helena Cruz Santos Ana Lucia Estevam Santos
Int J Biol Macromol
October 2020
Article Synopsis
- Lectins are proteins that have potential biological benefits, particularly in reducing inflammation and pain, which was the focus of a study evaluating their effects on zebrafish.
- The study specifically examined three plant lectins (DVL, VML, and PPL) to see if they could alleviate pain from menthol and capsaicin when injected into the fish, with the PPL lectin showing significant antinociceptive effects only against capsaicin.
- The findings suggested that not all lectins have the same pain-relieving properties, and the way they bind to carbohydrates may influence their effectiveness in reducing pain.