The effect of Fernblock® in preventing blue-light-induced oxidative stress and cellular damage in retinal pigment epithelial cells is associated with NRF2 induction.

Blue light exposure of the ocular apparatus is currently rising. This has motivated a growing concern about potential deleterious effects on different eye structures. To address this, ARPE-19 cells were used as a model of the retinal pigment epithelium and subjected to cumulative expositions of blue light.

The fungal-derived compound AM3 modulates pro-inflammatory cytokine production and skews the differentiation of human monocytes.

The proper functioning of the immune system depends on an appropriate balance between pro-inflammation and anti-inflammation. When the balance is disrupted and the system is excessively biased towards inflammation, immune responses cannot return within the normal range, which favors the onset of diseases of autoimmune or inflammatory nature. In this scenario, it is fundamental to find new compounds that can help restore this balance and contribute to the normal functioning of the immune system in humans.

Mitochondrial Stress Induces Plant Resistance Through Chromatin Changes.

Plants respond more efficiently when confronted with previous similar stress. In the case of pathogens, this memory of a previous infection confers resistance to future ones, which possesses a high potential for agricultural purposes. Some of the defense elements involved in this resistance phenotype, as well as epigenetic mechanisms participating in the maintenance of the memory, are currently known.

Oxylipins From Different Pathways Trigger Mitochondrial Stress Signaling Through Respiratory Complex III.

Plant oxylipins are signaling molecules produced from fatty acids by oxidative pathways, mainly initiated by 9- and 13-lipoxygenases (9-LOX and 13-LOX), alpha-dioxygenases or non-enzymatic oxidation. Oxylipins from the 9-LOX pathway induce oxidative stress and control root development and plant defense. These activities have been associated with mitochondrial processes, but precise cellular targets and pathways remain unknown.

Measuring Online Teaching Service Quality in Higher Education in the COVID-19 Environment.

The use of the Internet to develop new technologies has generated a considerable change in teaching and student learning in higher education. The pandemic caused by COVID-19 has forced universities to switch from face-to-face to online instruction. Furthermore, this transfer process was planned and executed quickly, with urgent redesigns of courses originally conceived for live teaching.

Costs and Benefits of Transgenerational Induced Resistance in Arabidopsis.

Recent evidence suggests that stressed plants employ epigenetic mechanisms to transmit acquired resistance traits to their progeny. However, the evolutionary and ecological significance of transgenerational induced resistance (t-IR) is poorly understood because a clear understanding of how parents interpret environmental cues in relation to the effectiveness, stability, and anticipated ecological costs of t-IR is lacking. Here, we have used a full factorial design to study the specificity, costs, and transgenerational stability of t-IR following exposure of to increasing stress intensities by a biotrophic pathogen, a necrotrophic pathogen, and salinity.

Long-Term Anorectal Manometry Outcomes After Laparoscopic and Transanal Total Mesorectal Excision.

During transanal total mesorectal excision (TaTME), sustained dilation of the anal canal occurs, which can cause anatomical and functional damage to the sphincter complex. This study aimed to analyze the impact of laparoscopic total mesorectal excision (LaTME) and TaTME in anorectal sphincter function. An observational study was conducted comparing two cohorts of patients who underwent LaTME or TaTME for rectal cancer.

Surviving in a Hostile World: Plant Strategies to Resist Pests and Diseases.

As primary producers, plants are under constant pressure to defend themselves against potentially deadly pathogens and herbivores. In this review, we describe short- and long-term strategies that enable plants to cope with these stresses. Apart from internal immunological strategies that involve physiological and (epi)genetic modifications at the cellular level, plants also employ external strategies that rely on recruitment of beneficial organisms.

The role of DNA (de)methylation in immune responsiveness of Arabidopsis.

DNA methylation is antagonistically controlled by DNA methyltransferases and DNA demethylases. The level of DNA methylation controls plant gene expression on a global level. We have examined impacts of global changes in DNA methylation on the Arabidopsis immune system.

K-space Prony's method for generating the basis functions of multi-Gaussian beam models.

The expansion coefficients of a multi-Gaussian ultrasonic beam model are obtained by a new approach that applies Prony s method in a K-space domain. This method allows the fitting of the Gaussian beam directly at the face of the transducer with very high computational efficiency. It is demonstrated that the K-space Prony's method can be used to accurately model the transducer field of planar and focused piston transducers, as well as probes that do not act as pistons.

Determination of an ultrasonic transducer's sensitivity and impedance in a pulse-echo setup.

The role that an ultrasonic piezoelectric transducer plays in an ultrasonic measurement system can be described in terms of the transducer's input electrical impedance and its sensitivity. Here, a new model-based approach is proposed to determine both the transducer impedance and sensitivity in a pulse-echo setup. This new method is much simpler to apply than previous "self-reciprocity" calibration methods for determining sensitivity and generalizes those methods.